ArticleJournal of ultrasound2017
Real-time elastography for the detection of fibrotic and inflammatory tissue in patients with stricturing Crohn's disease.
Article in Journal of ultrasound, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Diagnostic Accuracy of Intestinal Ultrasound in the Detection of Intra-Abdominal Complications in Crohn's Disease: A Systematic Review and Meta-Analysis.Journal of Crohn's & colitis · 2024Pooled it
- Ultrasound Elastography in Inflammatory Bowel Diseases: A Systematic Review of Accuracy Compared with Histopathological Assessment.Journal of Crohn's & colitis · 2022Pooled it
- Pooled it
- Integrating Intestinal Ultrasound in the Personalized Management of IBD.Journal of personalized medicine · 2026Review
- Multimodality ultrasound in Crohn's disease strictures.World journal of gastrointestinal pharmacology and therapeutics · 2026Article
- Elastography of the Intestinal Mucosa of Dogs With Chronic Inflammatory Enteropathy.Veterinary medicine international · 2026Article
- Elastography as a Discriminator Between Fibrotic and Inflammatory Strictures in Crohn's Disease: A Dead End or Bright Future in Clinical Decision-Making? Critical Review.Diagnostics (Basel, Switzerland) · 2024Review
- A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn's disease in clinical practice.Nature reviews. Gastroenterology & hepatology · 2024Article
- Novelties and Perspectives of Intestinal Ultrasound in the Personalised Management of Patients with Inflammatory Bowel Diseases-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Current Developments and Role of Intestinal Ultrasound including the Advent of AI.Diagnostics (Basel, Switzerland) · 2024Review
- Comprehensive review and update of stricturing Crohn's disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Ultrasound in Pediatric Inflammatory Bowel Disease-A Review of the State of the Art and Future Perspectives.Children (Basel, Switzerland) · 2024Review
- The Role of Transabdominal Ultrasound Elastography in Gastrointestinal Non-Liver Diseases: Current Application and Future Prospectives.Diagnostics (Basel, Switzerland) · 2023Review
- The Use of Transabdominal Ultrasound in Inflammatory Bowel Disease.Korean journal of radiology · 2022Review
- Review
- Ultrasound Elastography in the Assessment of the Intestinal Changes in Inflammatory Bowel Disease-Systematic Review.Journal of clinical medicine · 2021Review
- Shear Wave and Strain Elastography in Crohn's Disease-A Systematic Review.Diagnostics (Basel, Switzerland) · 2021Review
- Transvaginal Strain Elastosonography May Help in the Differential Diagnosis of Endometriosis?Diagnostics (Basel, Switzerland) · 2021Article
- Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn's Disease. The State of the Art.Frontiers in pharmacology · 2021Review
- Strain elastography in Crohn's disease: the role of visual observation and semiquantitative parameters.Journal of ultrasound · 2019Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe distinction between active inflammation and fibrosis of the bowel wall is essential for therapeutic decisions in stricturing Crohn's disease. We aimed to assess whether real-time elastography (RTE) with strain ratio measurement could be useful in differentiating fibrotic from inflamed bowel strictures and to evaluate the possible relationship between US techniques and the histology of the stenotic bowel wall. MATERIALS AND
methodsBowel ultrasonography (including RTE, color-Doppler and CEUS examination) was prospectively evaluated in 26 patients with symptomatic stricturing Crohn's disease, before surgery. RTE was adopted to evaluate bowel stiffness: five loops of 20 RTE frames were recorded for each stenotic segment and the mean strain ratio (MSR) was obtained. Histology scoring systems both for inflammation and fibrosis were established for surgical specimens.
resultsNo significant correlation was found between MSR and fibrosis score (
conclusionMSR detection was not able to distinguish fibrotic from inflammatory tissue in our selected population. This result could be influenced by the presence of the superimposed inflammation. Larger cohort of patients, further analysis with shear wave elastography, and validated histopathology classification systems for fibrosis and inflammation are necessary to assess if intestinal fibrosis could be reliably detected on the basis of bowel elastic properties.
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