Evidence map›Paper›PMID 29204146›Full record

ArticleFrontiers in immunology2017

Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis.

Jun Dai, Ajinkya Kumbhare, Dima Youssef, Charles E McCall, Mohamed El Gazzar

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 49 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Myeloid-derived suppressor cells in sepsis: drivers of persistent immunosuppression and targets for precision immunotherapy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. NuclearJournal of clinical & cellular immunology · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Here, There, and Everywhere: Myeloid-Derived Suppressor Cells in Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jun DaiDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, United States.
Ajinkya KumbhareDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, United States.
Dima YoussefDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, United States.
Charles E McCallSection of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Mohamed El GazzarDepartment of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN, United States.
East Tennessee State University · USWake Forest University · US

Funding

MicroRNAs and myeloid cell development during sepsisR01GM103887 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI ELGAZZAR, MOHAMED A. · 2013 to 2018
$1.4M
NIGMS NIH HHS R01 GM103887
6 · The paper itself

Abstract

Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA and intracellular protein levels increase during early sepsis and remain elevated in Gr1

Indexed as

immune suppressionmyeloid cell reprogrammingmyeloid-derived suppressor cellsS100A9sepsis

Identifiers

PMID29204146
PMCPMC5698275
OpenAlexW2768557607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.