ArticleFrontiers in physiology2017
Network Modularity in Breast Cancer Molecular Subtypes.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unveiling the Link Between Inflammation and Adaptive Immunity in Breast Cancer.Frontiers in immunology · 2019Pooled it
- Contrast-enhanced mammography based quantitative and qualitative feature analysis across different breast cancer molecular subtypes.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Single-Sample Networks Reveal Intra-Cytoband Co-Expression Hotspots in Breast Cancer Subtypes.International journal of molecular sciences · 2024Article
- Coordinated inflammation and immune response transcriptional regulation in breast cancer molecular subtypes.Frontiers in immunology · 2024Article
- The network structure of hematopoietic cancers.Scientific reports · 2023Article
- Pseudogenes in Cancer: State of the Art.Cancers · 2023Review
- CNVs in 8q24.3 do not influence gene co-expression in breast cancer subtypes.Frontiers in genetics · 2023Article
- The Breast Cancer Protein Co-Expression Landscape.Cancers · 2022Article
- Oncogenic Role of miR-217 During Clear Cell Renal Carcinoma Progression.Frontiers in oncology · 2022Article
- k-core genes underpin structural features of breast cancer.Scientific reports · 2021Article
- Highly connected, non-redundant microRNA functional control in breast cancer molecular subtypes.Interface focus · 2021Article
- Concepts and Applications of Information Theory to Immuno-Oncology.Trends in cancer · 2021Review
- Luminal A Breast Cancer Co-expression Network: Structural and Functional Alterations.Frontiers in genetics · 2021Article
- Loss of Long Distance Co-Expression in Lung Cancer.Frontiers in genetics · 2021Article
- Modularity in Biological Networks.Frontiers in genetics · 2021Review
- Gene Co-Expression in Breast Cancer: A Matter of Distance.Frontiers in oncology · 2021Article
- Identification of specific microRNA-messenger RNA regulation pairs in four subtypes of breast cancer.IET systems biology · 2020Article
- Gene Co-expression Is Distance-Dependent in Breast Cancer.Frontiers in oncology · 2020Article
- Gene Expression and Co-expression Networks Are Strongly Altered Through Stages in Clear Cell Renal Carcinoma.Frontiers in genetics · 2020Article
- LncRNA DANCR-miR-758-3p-PAX6 Molecular Network Regulates Apoptosis and Autophagy of Breast Cancer Cells.Cancer management and research · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is a heterogeneous and complex disease, a clear manifestation of this is its classification into different molecular subtypes. On the other hand, gene transcriptional networks may exhibit different modular structures that can be related to known biological processes. Thus, modular structures in transcriptional networks may be seen as manifestations of regulatory structures that tightly controls biological processes. In this work, we identify modular structures on gene transcriptional networks previously inferred from microarray data of molecular subtypes of breast cancer: luminal A, luminal B, basal, and HER2-enriched. We analyzed the modules (communities) found in each network to identify particular biological functions (described in the Gene Ontology database) associated to them. We further explored these modules and their associated functions to identify common and unique features that could allow a better level of description of breast cancer, particularly in the basal-like subtype, the most aggressive and poor prognosis manifestation. Our findings related to the immune system and a decrease in cell death-related processes in basal subtype could help to understand it and design strategies for its treatment.
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