ArticleCentral-European journal of immunology2017
Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency.
Article in Central-European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- B cells and T cells abnormalities in patients with selective IgA deficiency.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- In-depth blood immune profiling of Good syndrome patients.Frontiers in immunology · 2023Article
- Immune cytopenias as a continuum in inborn errors of immunity: An in-depth clinical and immunological exploration.Immunity, inflammation and disease · 2021Article
- Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum.Journal of clinical immunology · 2020Article
- Lymphocyte Subgroups and KREC Numbers in Common Variable Immunodeficiency: A Single Center Study.Journal of clinical immunology · 2020Article
- The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency.Clinical reviews in allergy & immunology · 2020Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
introductionPrevious studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder - selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. MATERIAL AND
methodsUsing flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naïve CD45RO
resultsAn increase of CD4
conclusionsOur results show T-cell activation not only in CVID, but also in IgAD patients. The increase in IgAD patients may be influenced by a more frequent CMV infection in our group of IgAD patients.
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