Evidence map›Paper›PMID 29204055›Full record

ArticleWorld journal of gastroenterology2017

Combined treatment of pancreatic cancer xenograft with

Winn Aung, Atsushi B Tsuji, Hitomi Sudo, Aya Sugyo, Yoshinori Ukai, Katsushi Kouda, Yoshikazu Kurosawa, Takako Furukawa, Tsuneo Saga, Tatsuya Higashi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Winn AungDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), Chiba 263-8555, Japan. winn.aung@qst.go.jp.
Atsushi B TsujiDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), Chiba 263-8555, Japan.
Hitomi SudoDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), Chiba 263-8555, Japan.
Aya SugyoDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), Chiba 263-8555, Japan.
Yoshinori UkaiPerseus Proteomics Inc., Tokyo 153-0041, Japan.
Katsushi KoudaPerseus Proteomics Inc., Tokyo 153-0041, Japan.
Yoshikazu KurosawaInnovation Center for Advanced Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Takako FurukawaDepartment of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan.
Tsuneo SagaDepartment of Diagnostic Radiology, Kyoto University Hospital, Kyoto 606-8507, Japan.
Tatsuya HigashiDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), Chiba 263-8555, Japan.
Ecogenomics (Japan) · JPNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the therapeutic effect of combined integrin α

methodsPhosphorylation of Akt, mTOR, the downstream effectors eukaryotic initiation factor 4E binding protein 1 (4EBP1) and S6 ribosomal protein (S6) were evaluated in BxPC-3 human pancreatic cancer cells treated with Yttrium-90 (

resultsWe found that phosphorylation of Akt (p-Akt), 4EBP1 (p-4EBP1) and S6 (p-S6) was inhibited by BEZ235. Colony formation in BxPC-3 cells was additively suppressed by the combination of

conclusionThe therapeutic efficacy of

Indexed as

AnimalsAntibodies, MonoclonalAntineoplastic AgentsCell Line, TumorFemaleHumansImidazolesIntegrin alpha6Integrin beta4Mice, NudePancreatic NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuinolinesRadioimmunotherapySignal TransductionAntibodies, MonoclonalAntineoplastic AgentsdactolisibImidazolesIntegrin alpha6Integrin beta4ITGA6 protein, humanITGB4 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuinolinesYttrium RadioisotopesAnti-integrin α6β4 antibodyNVP-BEZ235Pancreatic cancerRadioimmunotherapyYttrium-90

Identifiers

PMID29204055
PMCPMC5698248
OpenAlexW2767694207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.