ArticleNature neuroscience2018
Flexible timing by temporal scaling of cortical responses.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 238 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
238 citing papers in PubMed, 512 citations in OpenAlex.
- Article
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- Task-Parametrized dynamics: Representation of time and decisions in recurrent neural networks.Journal of computational neuroscience · 2026Article
- Neural dynamics underlying minute-timescale persistent behaviour in the human brain.Nature human behaviour · 2026Article
- Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Article
- Visual Simulation Is Supported by Sequential Monitoring in the Lateral Prefrontal Cortex.Journal of cognitive neuroscience · 2026Article
- Neural timescales from a computational perspective.Nature neuroscience · 2026Review
- Independence and coherence in temporal sequence computation across the fronto-parietal network.Nature communications · 2026Article
- Emergent representations of graphical structure in mechanistic neural models of causal judgment.bioRxiv : the preprint server for biology · 2026Article
- A specific basal forebrain-medial prefrontal cholinergic pathway improves attentional control in male mice.Scientific reports · 2026Article
- The speed limit of visual perception: Bidirectional influence of image memorability and processing speed on perceived duration and recognition.PLoS computational biology · 2026Article
- Neural Representation of Exogenous and Endogenous Temporal Expectations Based on fMRI.CNS neuroscience & therapeutics · 2026Article
- A brain-wide, trial- and time-dependent deterministic drive synergizes with within-trial noise to time self-initiated actions.bioRxiv : the preprint server for biology · 2026Article
- Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.Neurobiology of learning and memory · 2026Article
- The equilibrium point hypothesis revisited: why threshold control does not explain human movement.Experimental brain research · 2026Review
- Working Memory of Multi-Object Scenes in Primate Frontal Cortex.bioRxiv : the preprint server for biology · 2026Article
- Midbrain Dopamine Warps Subjective Time via Threshold Setting But Not Clock Speed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
178 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Musicians can perform at different tempos, speakers can control the cadence of their speech, and children can flexibly vary their temporal expectations of events. To understand the neural basis of such flexibility, we recorded from the medial frontal cortex of nonhuman primates trained to produce different time intervals with different effectors. Neural responses were heterogeneous, nonlinear, and complex, and they exhibited a remarkable form of temporal invariance: firing rate profiles were temporally scaled to match the produced intervals. Recording from downstream neurons in the caudate and from thalamic neurons projecting to the medial frontal cortex indicated that this phenomenon originates within cortical networks. Recurrent neural network models trained to perform the task revealed that temporal scaling emerges from nonlinearities in the network and that the degree of scaling is controlled by the strength of external input. These findings demonstrate a simple and general mechanism for conferring temporal flexibility upon sensorimotor and cognitive functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.