ArticleScientific reports2017
The Posterior Insula Shows Disrupted Brain Functional Connectivity in Female Migraineurs Without Aura Based on Brainnetome Atlas.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Brain network properties in chronic pain-a systematic review and meta-analysis of graph-based connectivity metrics.Frontiers in neuroscience · 2025Pooled it
- High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Trial
- Altered regional homogeneity in patients with diabetic vitreous hemorrhage.World journal of diabetes · 2020Trial
- Trial
- Changes in the functional brain networks and graph theory analysis of patients with epilepsy and comorbid migraine without aura.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Abnormal Functional Network Centrality and Causal Connectivity in Migraine Without Aura: A Resting-State fMRI Study.Brain and behavior · 2025Article
- Potential neural mechanisms of acupuncture therapy on migraine: a systematic review and activation likelihood estimation meta-analysis update.Quantitative imaging in medicine and surgery · 2025Article
- Aberrant dynamic functional network connectivity in vestibular migraine patients without peripheral vestibular lesion.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- White Matter Lesions Identified by Magnetic Resonance in Women with Migraine: A Volumetric Analysis and Clinical Correlations.Diagnostics (Basel, Switzerland) · 2023Article
- Increased hippocampal efficiency is associated with greater headache frequency in adolescents with chronic headache.Cerebral cortex communications · 2023Article
- Sex Differences in Chronic Migraine: Focusing on Clinical Features, Pathophysiology, and Treatments.Current pain and headache reports · 2022Review
- Abnormalities of Gray Matter Volume and Its Correlation with Clinical Symptoms in Adolescents with High-Functioning Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2022Article
- The value of brain MRI functional connectivity data in a machine learning classifier for distinguishing migraine from persistent post-traumatic headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura.Neural plasticity · 2022Article
- Structural Brain Network Abnormalities in Parkinson's Disease With Freezing of Gait.Frontiers in aging neuroscience · 2022Article
- Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura.Brain imaging and behavior · 2021Article
- Hyperconnection and hyperperfusion of overlapping brain regions in patients with menstrual-related migraine: a multimodal neuroimaging study.Neuroradiology · 2021Article
- Sex Differences of Periaqueductal Grey Matter Functional Connectivity in Migraine.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Disrupted White Matter Functional Connectivity With the Cerebral Cortex in Migraine Patients.Frontiers in neuroscience · 2021Article
- Article
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Authors and funding
20 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term headache attacks may cause human brain network reorganization in patients with migraine. In the current study, we calculated the topologic properties of functional networks based on the Brainnetome atlas using graph theory analysis in 29 female migraineurs without aura (MWoA) and in 29 female age-matched healthy controls. Compared with controls, female MWoA exhibited that the network properties altered, and the nodal centralities decreased/increased in some brain areas. In particular, the right posterior insula and the left medial superior occipital gyrus of patients exhibited significantly decreased nodal centrality compared with healthy controls. Furthermore, female MWoA exhibited a disrupted functional network, and notably, the two sub-regions of the right posterior insula exhibited decreased functional connectivity with many other brain regions. The topological metrics of functional networks in female MWoA included alterations in the nodal centrality of brain regions and disrupted connections between pair regions primarily involved in the discrimination of sensory features of pain, pain modulation or processing and sensory integration processing. In addition, the posterior insula decreased the nodal centrality, and exhibited disrupted connectivity with many other brain areas in female migraineurs, which suggests that the posterior insula plays an important role in female migraine pathology.
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