Evidence map›Paper›PMID 29203869›Full record

ArticleNature communications2017

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.

Andrea Romagnani, Valentina Vettore, Tanja Rezzonico-Jost, Sarah Hampe, Elsa Rottoli, Wiebke Nadolni, Michela Perotti, Melanie A Meier, Constanze Hermanns, Sheila Geiger and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Inter-Organellar CaCells · 2025
    Review
  8. Unlocking TRPM7 interactions: A database-driven quest.Computational and structural biotechnology journal · 2025
    Review
  9. Article
  10. Review
  11. Roles of TRP and PIEZO receptors in autoimmune diseases.Expert reviews in molecular medicine · 2024
    Review
  12. TRPM channels in health and disease.Nature reviews. Nephrology · 2024
    Review
  13. TRP Ion Channels in Immune Cells and Their Implications for Inflammation.International journal of molecular sciences · 2024
    Review
  14. The Role of TRPM7 in Oncogenesis.International journal of molecular sciences · 2024
    Review
  15. Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Ion channel regulation of gut immunity.The Journal of general physiology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 4 countries.

Andrea RomagnaniInstitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500, Bellinzona, Switzerland.
Valentina VettoreWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Tanja Rezzonico-JostInstitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500, Bellinzona, Switzerland.
Sarah HampeWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Elsa RottoliDepartment of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Via G.B. Viotti 3/5, 20133, Milan, Italy.
Wiebke NadolniWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Michela PerottiInstitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500, Bellinzona, Switzerland.
Melanie A MeierWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Constanze HermannsWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Sheila GeigerWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Gunther WennemuthInstitute for Anatomy, Universitätsklinikum Essen, Hufelandstrasse 55, 45147, Essen, Germany.ORCID http://orcid.org/0000-0003-3313-2475
Camilla RecordatiFilarete Foundation, Viale Ortles 22/4, 20139, Milan, Italy.
Masayuki MatsushitaDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Okinawa, 903-0215, Japan.
Susanne MuehlichWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Michele ProiettiInstitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500, Bellinzona, Switzerland.
Vladimir ChubanovWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Thomas GudermannWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany.
Fabio GrassiInstitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500, Bellinzona, Switzerland. fabio.grassi@irb.usi.ch.
Susanna ZierlerWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians Universität München, Goethestrasse 33, 80336, Munich, Germany. susanna.zierler@lrz.uni-muenchen.de.ORCID http://orcid.org/0000-0002-4684-0385
Ludwig-Maximilians-Universität München · DEUniversità della Svizzera italiana · CHUniversity of Milan · ITEssen University Hospital · DEFondazione Filarete · ITUniversity Medical Center Freiburg · DEUniversity of Bern · CHUniversity of the Ryukyus · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7

Indexed as

AnimalsAntigens, CDCell DifferentiationGenes, MHC Class IIGraft vs Host DiseaseIntegrin alpha ChainsIntestinesLymphopoiesisMiceMutationSmad2 ProteinTh17 CellsT-LymphocytesT-Lymphocytes, RegulatoryTransforming Growth Factor betaTRPM Cation Channelsalpha E integrinsAntigens, CDIntegrin alpha ChainsSmad2 ProteinSmad2 protein, mouseTransforming Growth Factor betaTrpm7 protein, mouseTRPM Cation Channels

Identifiers

PMID29203869
PMCPMC5714948
OpenAlexW2768099675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.