ArticleNature communications2017
ORAI channels are critical for receptor-mediated endocytosis of albumin.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- TH1177, Clemastine, and Benzhydryl Derivatives Act as Novel Extracellular Blockers of ORAI Channels.Biomolecules · 2026Article
- Hydraulic fracturing-induced delamination and extravasation extends medial damage beyond the false lumen in aortic dissection.bioRxiv : the preprint server for biology · 2026Article
- Illuminating Mouse Renal Proximal Tubule Architecture through High-Resolution Volume EM and Machine Learning Analysis.Journal of the American Society of Nephrology : JASN · 2026Article
- Endocytotic Albumin Uptake Pathways in Human Adipose Stem Cells and Connection to Intracellular Calcium Oscillations and the Neonatal Fc receptor.Cells, tissues, organs · 2026Article
- Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025Review
- Orai1 Expression and Vascular Function in Kidney Donors Determine Graft Outcomes at Short/Mid-Term.Cells · 2025Article
- Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy.Kidney research and clinical practice · 2024Article
- Calcium signalling and transport in the kidney.Nature reviews. Nephrology · 2024Review
- CaBiomolecules · 2023Article
- Store-operated CaExperimental biology and medicine (Maywood, N.J.) · 2023Review
- LncRNA MEG3 inhibits renal fibrinoid necrosis of diabetic nephropathy via the MEG3/miR-21/ORAI1 axis.Molecular biology reports · 2023Article
- ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Emerging roles of proximal tubular endocytosis in renal fibrosis.Frontiers in cell and developmental biology · 2023Review
- Ion channels and channelopathies in glomeruli.Physiological reviews · 2023Review
- Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension.International journal of molecular sciences · 2022Article
- Comprehensive Assessment of the STIMs and Orais Expression in Polycystic Ovary Syndrome.Frontiers in endocrinology · 2022Article
- Automatic Multi-functional Integration Program (AMFIP) towards all-optical mechano-electrophysiology interrogation.PloS one · 2022Article
- Insulin-activated store-operated CaNature communications · 2021Article
- Relationship between lysosomal dyshomeostasis and progression of diabetic kidney disease.Cell death & disease · 2021Review
- The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation.Cells · 2021Review
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 5 countries.
Funding
Abstract
Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PTECs and downregulated in patients with DN. Hyperglycemia or blockade of insulin signaling reduces the expression of ORAI1-3. Inhibition of ORAI channels by BTP2 and diethylstilbestrol or silencing of ORAI expression impairs albumin uptake. Transgenic mice expressing a dominant-negative Orai1 mutant (E108Q) increases albuminuria, and in vivo injection of BTP2 exacerbates albuminuria in streptozotocin-induced and Akita diabetic mice. The albumin endocytosis is Ca
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.