Evidence map›Paper›PMID 29203862›Full record

ArticleNature immunology2018

Diversification of human plasmacytoid predendritic cells in response to a single stimulus.

Solana G Alculumbre, Violaine Saint-André, Jeremy Di Domizio, Pablo Vargas, Philemon Sirven, Pierre Bost, Mathieu Maurin, Paolo Maiuri, Maxime Wery, Mabel San Roman and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 149 citations in OpenAlex.

  1. Trial
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Solana G AlculumbreInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Violaine Saint-AndréInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Jeremy Di DomizioDepartment of Dermatology, University Hospital CHUV, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6281-3918
Pablo VargasInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0002-6475-494X
Philemon SirvenInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Pierre BostInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Mathieu MaurinInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Paolo MaiuriInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0001-5079-445X
Maxime WeryInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Mabel San RomanInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Léa SaveyUMR7211 and Inflammation-Immunopathology-Biotherapy Departement (DHU i2B), Sorbonne Universités, UPMC Université de Paris, Paris, France.
Maxime TouzotAURA Paris Plaisance, Paris, France.
Benjamin TerrierDepartment of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases, Cochin Hospital, AP-HP, Université Paris Descartes, Paris, France.
David SaadounUMR7211 and Inflammation-Immunopathology-Biotherapy Departement (DHU i2B), Sorbonne Universités, UPMC Université de Paris, Paris, France.
Curdin ConradDepartment of Dermatology, University Hospital CHUV, Lausanne, Switzerland.
Michel GillietDepartment of Dermatology, University Hospital CHUV, Lausanne, Switzerland.
Antonin MorillonInstitut Curie, Centre de Recherche, PSL Research University, Paris, France.
Vassili SoumelisInstitut Curie, Centre de Recherche, PSL Research University, Paris, France. vassili.soumelis@curie.fr.ORCID http://orcid.org/0000-0003-1849-9834
Inserm · FRCentre National de la Recherche Scientifique · FRUniversity Hospital of Lausanne · CHUniversité Paris Cité · FRAssociation pour l'Utilisation du Rein Artificiel · FRDélégation Paris 5 · FRUniversité Paris Sciences et Lettres · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1

Indexed as

Adaptive ImmunityB7-1 AntigenB7-H1 AntigenCells, CulturedCytokinesDendritic CellsGene ExpressionGene Expression ProfilingHumansImmunity, InnateInterferon Type ILupus Erythematosus, SystemicMicroscopy, Electron, TransmissionOrthomyxoviridaePsoriasisB7-1 AntigenB7-H1 AntigenCD274 protein, humanCytokinesInterferon Type I

Identifiers

PMID29203862
OpenAlexW2775143705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.