ArticleScientific reports2017
Quantitative Analysis of Inflammation in Orbital Fat of Thyroid-associated Ophthalmopathy Using MRI Signal Intensity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Multiparametric MRI quantitative metrics for grading and staging graves' ophthalmopathy.BMC medical imaging · 2026Article
- MRI-based evaluation of orbital structures in relation to thyroid function in thyroid eye disease.Endocrine · 2026Article
- Radiological Activity Score (RAS)-MRI Characteristics in Dysthyroid Optic Neuropathy in a Multi-Ethnic Thyroid Eye Disease Population.Clinical endocrinology · 2025Article
- The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment.Ophthalmology and therapy · 2025Review
- Fat-suppression T2 relaxation time and water fraction predict response to intravenous glucocorticoid therapy for thyroid-associated ophthalmopathy.European radiology · 2025Article
- Application progress of magnetic resonance imaging in thyroid associated ophthalmopathy.Frontiers in endocrinology · 2025Review
- Dixon MRI-based quantitative parameters of extraocular muscles, intraorbital fat, and lacrimal glands for staging thyroid-associated ophthalmopathy.Insights into imaging · 2024Article
- Whole-orbit-based multiparametric assessment of disease activity of thyroid eye disease on Dixon MRI.International ophthalmology · 2024Article
- Efficacy and Safety of 6-Weekly versus 12-Weekly Intravenous Methylprednisolone in Moderate-to-Severe Active Thyroid-Associated Ophthalmopathy.Journal of clinical medicine · 2023Article
- Graves' Eye Disease: Clinical and Radiological Diagnosis.Biomedicines · 2023Review
- Research progress and application of artificial intelligence in thyroid associated ophthalmopathy.Frontiers in cell and developmental biology · 2023Review
- Extraocular muscle enlargement.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Review
- Advances in magnetic resonance imaging of orbital disease.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2022Article
- Effect of systemic steroid therapy in Graves' orbitopathy on regulatory T cells and Th17/Treg ratio.Journal of endocrinological investigation · 2021Article
- Dixon-T2WI magnetic resonance imaging at 3 tesla outperforms conventional imaging for thyroid eye disease.European radiology · 2021Article
- Detection of active and inactive phases of thyroid-associated ophthalmopathy using deep convolutional neural network.BMC ophthalmology · 2021Article
- The feasibility of quantitative MRI of extra-ocular muscles in myasthenia gravis and Graves' orbitopathy.NMR in biomedicine · 2021Article
- Article
- Radiological Staging of Thyroid-Associated Ophthalmopathy: Comparison of T1 Mapping with Conventional MRI.International journal of endocrinology · 2020Article
- Treatment with bimatoprost for exophthalmos in patients with inactive thyroid-associated ophthalmopathy.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
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3 authors.
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Abstract
We quantitatively analyzed inflammation in orbital fat from cases of thyroid-associated ophthalmopathy (TAO) using short-tau inversion recovery (STIR) sequences from magnetic resonance imaging. The signal intensity ratios (SIRs) of orbital fat as well as the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles on STIR images were measured in 70 eyes from 70 treatment-naive TAO patients (active TAO group, 19 patients; inactive TAO group, 51 patients) and 20 eyes from 20 controls. The mean SIR in the active TAO group was significantly higher than that in the inactive TAO group and controls (P < 0.001). The SIR of orbital fat in all TAO patients was significantly (P < 0.001) positively correlated with that of the extraocular muscles: SR (r = 0.64), IR (r = 0.55), LR (r = 0.58), MR (r = 0.71), and SO (r = 0.65). The SIR of orbital fat had a significant positive correlation with the CAS (r = 0.53, P < 0.001). The measurements of SIRs in orbital fat may be useful in evaluating the activity in tissues of TAO patients.
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