ArticleScientific reports2017
Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies.PLoS computational biology · 2025Article
- Principal component analysis of the Serological response to Plasmodium Falciparum using a Multiplex bead-based assay in Nigeria.Scientific reports · 2024Article
- Serodynamics: A primer and synthetic review of methods for epidemiological inference using serological data.Epidemics · 2024Review
- Clinical and immunological outcomes of HIV-exposed uninfected and HIV-unexposed uninfected children in the first 24 months of life in Western Kenya.BMC infectious diseases · 2024Article
- Determination of Plasmodium vivax and Plasmodium falciparum Malaria Exposure in Two Ethiopian Communities and Its Relationship to Duffy Expression.The American journal of tropical medicine and hygiene · 2023Article
- Serological Markers of Exposure to Plasmodium falciparum and Plasmodium vivax Infection in Southwestern Ethiopia.The American journal of tropical medicine and hygiene · 2023Article
- Impact of Agricultural Irrigation on Anemia in Western Kenya.The American journal of tropical medicine and hygiene · 2022Article
- Assessing Prevalence and Transmission Rates of Malaria through Simultaneous Profiling of Antibody Responses againstJournal of clinical medicine · 2022Article
- A unified and flexible modelling framework for the analysis of malaria serology data.Epidemiology and infection · 2021Article
- Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children.Immunity & ageing : I & A · 2021Article
- Antibody Profiles toThe American journal of tropical medicine and hygiene · 2020Article
- Sero-epidemiological evaluation of malaria transmission in The Gambia before and after mass drug administration.BMC medicine · 2020Article
- Reduced Transplacental Transfer of Antimalarial Antibodies in Kenyan HIV-Exposed Uninfected Infants.Open forum infectious diseases · 2019Article
Corrections and comments
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Authors and funding
17 authors at 13 institutions in 5 countries.
Funding
Abstract
We sought to identify a subset of Plasmodium falciparum antibody targets that would inform monitoring efforts needed to eliminate malaria in high transmission settings. IgG antibodies to 28 recombinant Pf antigens were measured in residents of two communities in western Kenya examined in 2003 and 2013, when the respective prevalence of asymptomatic parasitemia among children was 81 and 15 percent by microscopy. Annual seroconversion rates based on a sero-catalytic model that dichotomised antibody values to negative versus positive showed that rates were higher in 2003 than 2013 for 1 pre-erythrocytic and 7 blood-stage antigens. Antibody acquisition models that considered antibody levels as continuous variables showed that age-related antibody levels to Circumsporozoite Protein and 10 merozoite proteins increased at different rates with age in 2003 versus 2013. Both models found that antibodies to 5 proteins of the Merozoite Surface Protein 1 complex were differentially acquired between the cohorts, and that changes in antibody levels to Apical Membrane Antigen 1 suggested a decrease in transmission that occurred ~10 years before 2013. Further studies evaluating antibodies to this subset of Pf antigens as biomarkers of malaria exposure and naturally acquired immunity are warranted in endemic settings where transmission has been reduced but persists.
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