Evidence map›Paper›PMID 29203632›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.

Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Observational
  7. Review
  8. Article
  9. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Current updates and future perspectives in uric acid research, 2024.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Masanari KuwabaraFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.). kuwamasa728@gmail.com.
Ichiro HisatomeFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Koichiro NiwaFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Shigeko HaraFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Carlos A Roncal-JimenezFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Petter BjornstadFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Takahiko NakagawaFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Ana Andres-HernandoFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Yuka SatoFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Thomas JensenFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Gabriela GarciaFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Bernardo Rodriguez-IturbeFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Minoru OhnoFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Miguel A LanaspaFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).
Richard J JohnsonFrom the Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora (M.K., C.A.R.-J., P.B., A.A.-H., Y.S., T.J., G.G., M.A.L., R.J.J.); Department of Cardiology (M.K., M.O.) and Health Management Center (S.H.), Toranomon Hospital, Tokyo, Japan; Cardiovascular Center, St. Luke's International Hospital, Tokyo, Japan (M.K., K.N.); Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan (I.H.); Children's Hospital Colorado and Barbara Davis Center for Childhood Diabetes, Aurora (P.B.); Department of Future Basic Medicine, Nara Medical University, Japan (T.N.); and Department of Nephrology, Hospital Universitario and Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Maracaibo (B.R.-I.).

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Dietary Salt has an Unrecognized Role in Modulating Energy Intake and Metabolic SyndromeR01DK108408 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, RICHARD JOSEPH · 2016 to 2019
$1.6M
NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK108408
6 · The paper itself

Abstract

Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid levels. The additional analysis evaluated whether serum uric acid (hyperuricemia) constituted an independent risk factor for developing hypertension. The cumulative incidence of hypertension from prehypertension over 5 years was 25.3%. There were no significant differences between women and men (24.4% versus 26.0%;

Indexed as

HypertensionPrehypertensionAdultAgedAge FactorsBlood PressureBody Mass IndexCohort StudiesDisease ProgressionFemaleHumansIncidenceJapanMaleMiddle AgedRisk FactorsUric Acidblood pressurediabetes mellitusepidemiologyhyperuricemiarisk factorsuric acid

Identifiers

PMID29203632
PMCPMC5730471

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.