Evidence map›Paper›PMID 29203629›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black Men.

Jennifer R Vranish, Seth W Holwerda, Benjamin E Young, Daniel P Credeur, Jordan C Patik, Thales C Barbosa, David M Keller, Paul J Fadel

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04770155 (Vascular Dysfunction in Black Individuals), which is not on this map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04770155 early_phase1terminatednot on this mapstarted 2021, after this paper: background citation

Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1

TypeinterventionalSponsorUniversity of Mississippi Medical CenterRan2021 to 2021Enrolled8ConditionsVascular Function, Racial DisparityArmsDietary Nitrates 400 mg, L-citrulline 3 g, Sildenafil 100 mg, Bosentan 125 mg
3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Trial
  2. Trial
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  5. Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Trial
  6. Trial
  7. Resting sympathetic transduction in veterans with PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  8. Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  9. Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans.Journal of racial and ethnic health disparities · 2026
    Article
  10. Review
  11. Article
  12. Review
  13. Cardiac autonomic function in young, healthy adults: Influence of race and sex.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  14. Sympathetic transduction to blood pressure in patients with chronic kidney disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jennifer R VranishFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.).
Seth W HolwerdaFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.).
Benjamin E YoungFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.).
Daniel P CredeurFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.).
Jordan C PatikFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.).
Thales C BarbosaFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.).
David M KellerFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.).
Paul J FadelFrom the Department of Kinesiology, University of Texas at Arlington (J.R.V., B.E.Y., J.C.P., T.C.B., D.M.K., P.J.F.); School of Kinesiology, University of Southern Mississippi, Hattiesburg (D.P.C.); and Department of Health and Human Physiology, University of Iowa, Iowa City (S.W.H.). paul.fadel@uta.edu.

Funding

Targeting Sympathetic Overactivity in CKD patients: Mechanisms & Novel TherapiesR01HL127071 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI FADEL, PAUL J · 2016 to 2019
$1.7M
Sympathetic baroreflex control and vascular transduction in African AmericansR15HL130906 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI KELLER, DAVID M · 2016 to 2016
$377k
NHLBI NIH HHS R01 HL127071NHLBI NIH HHS R15 HL130906
6 · The paper itself

Abstract

Blacks have the highest prevalence of hypertension, putting them at greater risk of cardiovascular disease and death. Previous studies have reported that, relative to whites, healthy black men have augmented pressor responses to sympathoexcitatory stressors. Although important, these studies do not inform about the resting state and the influence of spontaneous changes in resting muscle sympathetic nerve activity (MSNA). Likewise, little is known about the transduction of MSNA into a vascular response at rest on a beat-to-beat basis. Accordingly, we tested the hypothesis that relative to whites, blacks would exhibit greater vasoconstriction and pressor responses following spontaneous bursts of MSNA. Mean arterial pressure, common femoral artery blood flow, and MSNA were continuously recorded during 20 minutes of supine rest in 35 young healthy men (17 blacks and 18 whites). Signal averaging was used to characterize changes in leg vascular conductance, total vascular conductance, and mean arterial pressure following spontaneous MSNA bursts. Blacks demonstrated significantly greater decreases in leg vascular conductance (blacks: -15.0±1.0%; whites: -11.5±1.2%;

Indexed as

Muscle, Smooth, VascularAdultBlack or African AmericanBlood PressureFemoral ArteryHeart RateHemodynamicsHumansMaleRestSympathetic Nervous SystemUnited StatesVascular ResistanceVasoconstrictionWhite Peopleblood pressurefemoral arterymuscle sympathetic nerve activityprevalenceracevascular conductancevasoconstriction

Identifiers

PMID29203629
PMCPMC6086345

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.