ArticleCirculation2017
Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery.
Abstract readLetter
In one paragraph
Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Continuous postoperative pericardial flushing to reduce the risk of postoperative bleeding after elective adult cardiac surgery - a study-level meta-analysis.Journal of cardiothoracic surgery · 2025Pooled it
- Active clearance vs conventional management of chest tubes after cardiac surgery: a randomized controlled study.Journal of cardiothoracic surgery · 2021Trial
- Continuous postoperative pericardial flushing method versus standard care for wound drainage after adult cardiac surgery: A randomized controlled trial.EBioMedicine · 2020Trial
- Potential Clinical Application of Determination of Bisphenols in Pericardial Fluid from Patients with Coronary Artery Disease.Molecules (Basel, Switzerland) · 2026Article
- Pericardial Inflammatory Mediators in Patients Undergoing Cardiac Surgery: Towards a Biomarker-Informed Clinical Practice.Reviews in cardiovascular medicine · 2026Review
- Effects of Continuous Postoperative Pericardial FLUshing with Investigational Device on Postoperative Re-Explorations for Bleeding (FLUID)-Randomized Clinical Trial.Journal of clinical medicine · 2026Article
- Preventing Postpericardiotomy Syndrome: Current Evidence and Future Directions.Journal of cardiovascular development and disease · 2026Review
- The Molecular Relationship Between SDF4 and Thiol/Disulfide Homeostasis and Cardiac Injury Markers in Serum and Pericardial Fluid of Patients Undergoing Open-Heart Surgery.Journal of clinical medicine · 2025Article
- Probing the Relationship Between Perioperative Complications in Patients With Valvular Heart Disease: Network Analysis Based on Bayesian Network.JMIR formative research · 2025Article
- Potential Clinical Application of Analysis of Bisphenols in Pericardial Fluid from Patients with Coronary Artery Disease with the Use of Liquid Chromatography Combined with Fluorescence Detection and Triple Quadrupole Mass Spectrometry.Molecules (Basel, Switzerland) · 2025Article
- Compartmentalization of the Inflammatory Response in the Pericardial Cavity in Patients Undergoing Cardiac Surgery.International journal of molecular sciences · 2024Article
- Pericardial Fluid of Patients With Coronary Artery Disease Can Drive Fibrosis Via TGF-Beta Pathway.JACC. Basic to translational science · 2024Article
- Charting New Real Estate: Leveraging the Therapeutic Potential of the Pericardial Space.JACC. Basic to translational science · 2024Article
- Small Extracellular Vesicles in the Pericardium Modulate Macrophage Immunophenotype in Coronary Artery Disease.JACC. Basic to translational science · 2024Article
- Cardiac fibrogenesis: an immuno-metabolic perspective.Frontiers in physiology · 2024Review
- Cardiac surgery elicits pericardial inflammatory responses that are distinct compared with postcardiopulmonary bypass systemic inflammation.JTCVS open · 2023Article
- Feasibility study of intraoperative pericardial fluid biomarkers and length of stay after cardiac surgery.JTCVS techniques · 2023Article
- Impact of early pericardial fluid chymase activation after cardiac surgery.Frontiers in cardiovascular medicine · 2023Article
- Does the Naked Emperor Parable Apply to Current Perceptions of the Contribution of Renin Angiotensin System Inhibition in Hypertension?Current hypertension reports · 2022Review
- Comprehensive characterization of the postoperative pericardial inflammatory response: Potential implications for clinical outcomes.JTCVS open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Brittany ButtsDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
Lee A GoeddelDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
David J GeorgeDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
Chad SteeleDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
James E DaviesDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
Chih-Chang WeiDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
Jasmina VaragicDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
James F GeorgeDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
Carlos M FerrarioDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
Spencer J MelbyDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.).
Louis J Dell'ItaliaDepartment of Veterans Affairs Medical Center, Birmingham, AL (J.E.D., C.-C.W., L.J.D.). Department of Medicine, Division of Cardiovascular Disease (B.B., C.-C.W., L.J.D.); Division of Pulmonary, Allergy and Critical Care (C.S.); Department of Surgery, Division of Cardiothoracic Surgery (D.J.G., J.F.G.), University of Alabama at Birmingham. Department of Surgery, Wake Forest University Health Science Center, Winston-Salem, NC (J.V., C.M.F.). Department of Surgery, Division of Cardiothoracic Surgery, Washington University, Saint Louis, MO, and Saint Louis VA Medical Center (S.J.M.). Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (L.A.G.). louis.dellitalia@va.gov.
Funding
Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VARAGIC, JASMINA · 1994 to 2019
$34.8MInterdisciplinary Training in Pathobiology and Rehabilitation Medicine.T32HD071866 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES RIMMER, Anna E. Thalacker-Mercer · 2012 to 2026
$4.8MSymptoms and Skeletal Muscle in Persons with Heart Failure with Preserved Ejection FractionF32NR017322 · NINR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUTTS, BRITTANY · 2017 to 2018
$68kThe Chymase Angiotensin-(1-12) Axis in Heart DiseaseI01CX000993 · VA · BIRMINGHAM VA MEDICAL CENTER · PI DELL'ITALIA, LOUIS J. · 2014 to 2017
–CSRD VA I01 CX000993NHLBI NIH HHS P01 HL051952NICHD NIH HHS T32 HD071866NINR NIH HHS F32 NR017322
Abstract
PubMed holds no abstract for this paper.
Indexed as
Atrial FibrillationBiomarkersCardiac Surgical ProceduresDrainageFemaleHumansInflammation MediatorsMaleMiddle AgedPericardial FluidRisk FactorsTime FactorsUp-RegulationBiomarkersInflammation Mediatorsanti-inflammatory agentsatrial fibrillationneutrophilspericardial fluidthoracic surgery
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.