Evidence map›Paper›PMID 29203562›Full record

ArticleCirculation. Heart failure2017

Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor.

Justin Hartupee, Gabor D Szalai, Wei Wang, Xiucui Ma, Abhinav Diwan, Douglas L Mann

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Cardiac effects and toxicity of chloroquine: a short update.International journal of antimicrobial agents · 2020
    Review
  9. Article
  10. CaMKII Activity in the Inflammatory Response of Cardiac Diseases.International journal of molecular sciences · 2019
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Justin HartupeeFrom the Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.H., X.M., A.D., D.L.M.); John Cochran VA Medical Center, St. Louis, MO (A.D.); and Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (G.D.S., W.W.).
Gabor D SzalaiFrom the Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.H., X.M., A.D., D.L.M.); John Cochran VA Medical Center, St. Louis, MO (A.D.); and Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (G.D.S., W.W.).
Wei WangFrom the Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.H., X.M., A.D., D.L.M.); John Cochran VA Medical Center, St. Louis, MO (A.D.); and Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (G.D.S., W.W.).
Xiucui MaFrom the Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.H., X.M., A.D., D.L.M.); John Cochran VA Medical Center, St. Louis, MO (A.D.); and Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (G.D.S., W.W.).
Abhinav DiwanFrom the Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.H., X.M., A.D., D.L.M.); John Cochran VA Medical Center, St. Louis, MO (A.D.); and Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (G.D.S., W.W.).
Douglas L MannFrom the Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO (J.H., X.M., A.D., D.L.M.); John Cochran VA Medical Center, St. Louis, MO (A.D.); and Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (G.D.S., W.W.). dmann@wustl.edu.
John Cochran VA Medical Center · US

Funding

PRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6M
ROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9M
CYTOPROTECTIVE EFFECTS OF INFLAMMATION MEDIATED MEMBRANE REPAIRR01HL111094 · NHLBI · WASHINGTON UNIVERSITY · PI MANN, DOUGLAS L · 2012 to 2016
$1.9M
Cardiac Inflammation in Resuscitated Hemorrhagic ShockR01HL073017 · NHLBI · WASHINGTON UNIVERSITY · PI MANN, DOUGLAS L · 2005 to 2008
$1.4M
CAUSE AND CONSEQUENCE OF TNF OVEREXPRESSION IN THE HEARTR01HL058081 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MANN, DOUGLAS LOWELL · 1998 to 2007
$1.4M
Cytoprotective Cytokine Signaling and Reperfusion InjuryR01HL089543 · NHLBI · WASHINGTON UNIVERSITY · PI MANN, DOUGLAS L · 2009 to 2010
$779k
Enhancing Beneficial Autophagy to Prevent Heart FailureI01BX001969 · VA · ST. LOUIS VA MEDICAL CENTER · PI DIWAN, ABHINAV · 2014 to 2017
–
BLRD VA I01 BX001969NHLBI NIH HHS R01 HL058081NHLBI NIH HHS R01 HL073017NHLBI NIH HHS R01 HL089543NHLBI NIH HHS R01 HL107594NHLBI NIH HHS R01 HL111094NHLBI NIH HHS T32 HL007081
6 · The paper itself

Abstract

backgroundSustained inflammation in the heart is sufficient to provoke left ventricular dysfunction and left ventricular remodeling. Although inflammation has been linked to many of the biological changes responsible for adverse left ventricular remodeling, the relationship between inflammation and protein quality control in the heart is not well understood. METHODS AND

resultsTo study the relationship between chronic inflammation and protein quality control, we used a mouse model of dilated cardiomyopathy driven by cardiac restricted overexpression of TNF (tumor necrosis factor;

conclusions

Indexed as

Ventricular Function, LeftVentricular RemodelingAnimalsAutophagosomesAutophagyCardiomyopathy, DilatedDisease Models, AnimalGenetic Predisposition to DiseaseHeart FailureHeart VentriclesHumansInflammation MediatorsMechanistic Target of Rapamycin Complex 1Mice, TransgenicMyocytes, CardiacMyosin Heavy ChainsATP dependent 26S proteaseInflammation MediatorsMechanistic Target of Rapamycin Complex 1Myh6 protein, mouseMyosin Heavy ChainsProteasome Endopeptidase ComplexProtein AggregatesTumor Necrosis Factor-alphaautophagyinflammationmyocarditistumor necrosis factorubiquitin

Identifiers

PMID29203562
PMCPMC5728663
OpenAlexW2771801063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.