Evidence map›Paper›PMID 29203547›Full record

ArticleInfection and immunity2018

Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System.

Steven T Denham, Surbhi Verma, Raymond C Reynolds, Colleen L Worne, Joshua M Daugherty, Thomas E Lane, Jessica C S Brown

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 64 citations in OpenAlex.

  1. Set202 is a histone lysine methyltransferase that enablesbioRxiv : the preprint server for biology · 2026
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  5. Iturin A disruptsNpj fungal science · 2026
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  9. Lack of an atypical PDR transporter generates an immunogenicbioRxiv : the preprint server for biology · 2025
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  10. Review
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  12. Frontiers in immunology · 2025
    Article
  13. Article
  14. United toward a common goal: Coordination of microbial virulence phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Phenotypic characterization ofMicrobiology spectrum · 2024
    Article
  17. Phenotypic characterization ofbioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Steven T DenhamDivision of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0002-3982-3835
Surbhi VermaDivision of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0001-6974-0267
Raymond C ReynoldsDivision of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Colleen L WorneDivision of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Joshua M DaughertyDivision of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Thomas E LaneDivision of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Jessica C S BrownDivision of Microbiology and Immunology, Pathology Department, University of Utah School of Medicine, Salt Lake City, Utah, USA jessica.brown@path.utah.edu.ORCID 0000-0002-3255-1486
University of Utah · US

Funding

Chemokines and Viral-Induced Neurologic DiseaseR01NS041249 · NINDS · UNIVERSITY OF UTAH · PI LANE, THOMAS E · 2002 to 2019
$5.4M
NINDS NIH HHS R01 NS041249
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCentral Nervous SystemCryptococcosisCryptococcus neoformansFemaleFungal PolysaccharidesLung Diseases, FungalMiceMice, Inbred C57BLMutationVirulenceFungal PolysaccharidescapsuleCryptococcus neoformansglucuronoxylomannanhost-pathogen interactionimmune suppressionvirulence

Identifiers

PMID29203547
PMCPMC5820953
OpenAlexW2952483973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.