Evidence map›Paper›PMID 29203511›Full record

ArticleDiabetes2018

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Kevin C Corbit, João Paulo G Camporez, Lia R Edmunds, Jennifer L Tran, Nicholas B Vera, Derek M Erion, Rahul C Deo, Rachel J Perry, Gerald I Shulman, Michael J Jurczak and 1 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Relationship between Indel Variants within theAnimals : an open access journal from MDPI · 2024
    Article
  3. Association BetweenInternational journal of general medicine · 2023
    Article
  4. Acute exercise rapidly activates hepatic mitophagic flux.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  5. Article
  6. PRL/PRLR Can Promote Insulin Resistance by Activating the JAK2/STAT5 Signaling Pathway.Computational and mathematical methods in medicine · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Effect of growth hormone on insulin signaling.Molecular and cellular endocrinology · 2020
    Review
  11. Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.Environmental science and pollution research international · 2020
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Kevin C CorbitCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.
João Paulo G CamporezDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT.
Lia R EdmundsDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Jennifer L TranCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.
Nicholas B VeraCardiovascular and Metabolic Diseases, Pfizer, Cambridge, MA.
Derek M ErionCardiovascular and Metabolic Diseases, Pfizer, Cambridge, MA.
Rahul C DeoCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.
Rachel J PerryDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT.
Gerald I ShulmanDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-1529-5668
Michael J JurczakDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
Ethan J WeissCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA ethan.weiss@ucsf.edu.ORCID 0000-0001-9936-5816
University of California, San Francisco · USPfizer (United States) · USUniversity of Pittsburgh · USYale University · USHoward Hughes Medical Institute · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Yale Mouse Metabolic Phenotyping CenterU24DK059635 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2001 to 2015
$8.9M
T32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3M
Mechanisms of Lipid-Induced Hepatic Insulin ResistanceR01DK040936 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 1989 to 2015
$5.1M
Growth hormone signaling and lipid metabolism in fatty liver diseaseR01DK091276 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISS, ETHAN · 2011 to 2015
$1.7M
Parkin's role in hepatic mitochondrial turnover, steatosis and insulin resistanceK01DK099402 · NIDDK · YALE UNIVERSITY · PI JURCZAK, MICHAEL J. · 2013 to 2015
$441k
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS K01 DK099402NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK040936NIDDK NIH HHS R01 DK091276NIDDK NIH HHS T32 DK007052NIDDK NIH HHS U24 DK059635NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

Disruption of hepatocyte growth hormone (GH) signaling through disruption of

Indexed as

Insulin ResistanceAdipose TissueAdiposityAnimalsDiet, High-FatJanus Kinase 2Lipid MetabolismLiverMice, Inbred C57BLMice, KnockoutMice, TransgenicNon-alcoholic Fatty Liver DiseaseObesityOrgan SpecificityPhosphoproteinsPhosphorylationJak2 protein, mouseJanus Kinase 2Phosphoproteinsproline-rich Akt substrate, 40 kDa protein, mouseProto-Oncogene Proteins c-aktThreonine

Identifiers

PMID29203511
PMCPMC5780061
OpenAlexW2772380625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.