ArticleJournal of the American Academy of Dermatology2020
Age-dependent interaction between sex and geographic ultraviolet index in melanoma risk.
Article in Journal of the American Academy of Dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Cutaneous melanoma in Kazakhstan: epidemiological trends and economic burden on the healthcare system.Archives of public health = Archives belges de sante publique · 2026Article
- Global, regional, and national burden of premenopausal and postmenopausal malignant melanoma from 1990 to 2021: a comprehensive cross-sectional analysis.American journal of cancer research · 2025Article
- Geospatial Patterns of Non-Melanoma Skin Cancer in Relation to Climate Changes in Iran.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Article
- Advances in Early Detection of Melanoma and the Future of At-Home Testing.Life (Basel, Switzerland) · 2023Review
- Clinical significance and immune landscape of KIR2DL4 and the senescence-based signature in cutaneous melanoma.Cancer science · 2022Article
- An Updated Algorithm Integrated With Patient Data for the Differentiation of Atypical Nevi From Early Melanomas: the idScore 2021.Dermatology practical & conceptual · 2022Article
- Etiologies of Melanoma Development and Prevention Measures: A Review of the Current Evidence.Cancers · 2021Review
- The Sex Differences in Uveal Melanoma: Potential Roles of EIF1AX, Immune Response and Redox Regulation.Current oncology (Toronto, Ont.) · 2021Article
- Sex disparity in skin carcinogenesis and potential influence of sex hormones.Skin health and disease · 2021Review
- Landscape and Clinical Significance of Immune Checkpoint in Cutaneous Melanoma.Frontiers in immunology · 2021Article
- Mechanisms of JAK-STAT signaling pathway mediated by CXCL8 gene silencing on epithelial-mesenchymal transition of human cutaneous melanoma cells.Oncology letters · 2020Article
- A Possible Link of Genetic Variations in ER/IGF1R Pathway and Risk of Melanoma.International journal of molecular sciences · 2020Article
- Opposite Roles of BAP1 in Overall Survival of Uveal Melanoma and Cutaneous Melanoma.Journal of clinical medicine · 2020Article
- Race-, Age-, and Anatomic Site-Specific Gender Differences in Cutaneous Melanoma Suggest Differential Mechanisms of Early- and Late-Onset Melanoma.International journal of environmental research and public health · 2019Article
- Beyond the physician's perspective: A review of patient-reported outcomes in dermatologic surgery and cosmetic dermatology.International journal of women's dermatology · 2019Review
- The World of Melanoma: Epidemiologic, Genetic, and Anatomic Differences of Melanoma Across the Globe.Current oncology reports · 2018Review
- A cancer registry-based analysis on the non-white populations reveals a critical role of the female sex in early-onset melanoma.Cancer causes & control : CCC · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundUltraviolet (UV) exposure may not affect melanoma development equally in different sexes and ages. Whether and how these factors interact with each other in relation to melanoma risk is unknown.
objectiveThis study attempts to estimate interactions among UV index (UVI), sex, and age in melanoma risk.
methodsMelanoma incidence data were collected from 42 cancer registries. Geographic UVI was collected from local satellite stations. Negative binomial regression models were used to estimate the impact of each risk factor and their interactions.
resultsSex, UVI, and age, as well as interactions between any 2 of these factors, were significantly associated with melanoma risk. In younger age groups, female sex is an independent risk factor for melanoma that is not affected by ambient UV exposure. In older age groups, however, female sex interacts with UV exposure as a risk factor, exhibiting a protective effect. The switching age category is 45 to 49, which correlates with dramatic hormonal changes. LIMITATIONS: The interaction between sex and UVI is measured at an ecologic level.
conclusionsThe interaction between sex and UVI is age dependent. Female sex is an independent risk factor for early-onset melanoma, but female sex also protects against UV-associated melanoma in older age groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.