Evidence map›Paper›PMID 29203422›Full record

ReviewNeuroscience and biobehavioral reviews2018

Pavlovian conditioned diminution of the neurobehavioral response to threat.

Adam M Goodman, Nathaniel G Harnett, David C Knight

Registry-linked trialAbstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05854160 (Stimulation-Induced Changes in Fronto-Limbic Connectivity Control Regulation of the Emotional Response to Threat), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05854160 narecruitingnot on this mapstarted 2023, after this paper: background citation

Stimulation-Induced Changes in Fronto-Limbic Connectivity Control Regulation of the Emotional Response to Threat

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2023 to 2027Enrolled30ConditionsEpilepsy, Mental DisordersArmsElectrical Pulse Train Stimulation
3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Sex-related differences in violence exposure, neural reactivity to threat, and mental health.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  13. Article
  14. Article
  15. Neurocircuitry of Contingency Awareness in Pavlovian Fear Conditioning.Cognitive, affective & behavioral neuroscience · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam M GoodmanDepartment of Psychology, University of Alabama at Birmingham, CIRC 235 H, 1720 2nd Avenue South, Birmingham, AL 35294-1170, United States.
Nathaniel G HarnettDepartment of Psychology, University of Alabama at Birmingham, CIRC 235 H, 1720 2nd Avenue South, Birmingham, AL 35294-1170, United States.
David C KnightDepartment of Psychology, University of Alabama at Birmingham, CIRC 235 H, 1720 2nd Avenue South, Birmingham, AL 35294-1170, United States. Electronic address: knightdc@uab.edu.

Funding

Neurobiological Mechanisms of Lower Internalizing Disorders in Black AmericansR01MH098348 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KNIGHT, DAVID C, MRUG, SYLVIE · 2012 to 2016
$2.9M
NIMH NIH HHS R01 MH098348
6 · The paper itself

Abstract

An important function of emotion is that it motivates us to respond more effectively to threats in our environment. Accordingly, healthy emotional function depends on the ability to appropriately avoid, escape, or defend against threats we encounter. Thus, from a functional perspective, it is important to understand the emotional response to threat. However, prior work has largely focused on the emotional response in anticipation of threat, rather than the emotional response to the threat itself. The current review is focused on recent behavioral, psychophysiological, and neural findings from Pavlovian conditioning research that is centered on the expression and regulation of the emotional response to threat. The current evidence suggests that a neural network that includes the prefrontal cortex, hippocampus, and amygdala underlies learning, expression, and regulation processes that modulate emotional responses to threat. This line of research has important implications for our understanding of emotion regulation and stress resilience.

Indexed as

AmygdalaConditioning, ClassicalFearHippocampusHumansPrefrontal CortexEmotionfMRILearningPavlovian conditioningRegulationThreatUCR

Identifiers

PMID29203422
PMCPMC5744889

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.