Evidence map›Paper›PMID 29203346›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2018

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.

Gregor Sachse, Chris Church, Michelle Stewart, Heather Cater, Lydia Teboul, Roger D Cox, Frances M Ashcroft

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. m6A demethylase FTO and osteoporosis: potential therapeutic interventions.Frontiers in cell and developmental biology · 2023
    Review
  9. Review
  10. Calmodulin as CaInternational journal of molecular sciences · 2021
    Article
  11. Article
  12. MiR-103-3p targets the mAging cell · 2021
    Article
  13. Novel Insights Into the Multifaceted Functions of RNA nFrontiers in cell and developmental biology · 2021
    Review
  14. Review
  15. Regulatory Role of the RNA NFrontiers in cell and developmental biology · 2020
    Review
  16. The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Regulatory Role of RNA NFrontiers in endocrinology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gregor SachseDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. Electronic address: gregor.sachse@dpag.ox.ac.uk.
Chris ChurchMRC Harwell Institute, Mammalian Genetics Unit and Mary Lyon Centre, Harwell Campus, Oxfordshire, OX11 0RD, UK. Electronic address: churchc@MedImmune.com.
Michelle StewartMRC Harwell Institute, Mammalian Genetics Unit and Mary Lyon Centre, Harwell Campus, Oxfordshire, OX11 0RD, UK. Electronic address: m.stewart@har.mrc.ac.uk.
Heather CaterMRC Harwell Institute, Mammalian Genetics Unit and Mary Lyon Centre, Harwell Campus, Oxfordshire, OX11 0RD, UK. Electronic address: h.cater@har.mrc.ac.uk.
Lydia TeboulMRC Harwell Institute, Mammalian Genetics Unit and Mary Lyon Centre, Harwell Campus, Oxfordshire, OX11 0RD, UK. Electronic address: l.teboul@har.mrc.ac.uk.
Roger D CoxMRC Harwell Institute, Mammalian Genetics Unit and Mary Lyon Centre, Harwell Campus, Oxfordshire, OX11 0RD, UK. Electronic address: r.cox@har.mrc.ac.uk.
Frances M AshcroftDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. Electronic address: frances.ashcroft@dpag.ox.ac.uk.

Funding

Medical Research Council MC_U142661184Medical Research Council MC_UP_1502/1Medical Research Council MC_UP_1502/3Wellcome Trust 084655Wellcome Trust 089795
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Protein MethyltransferasesAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsAnimals, NewbornBone DevelopmentCalcification, PhysiologicFemaleMaleMiceMice, Inbred C57BLMice, KnockoutAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, mouseProtein MethyltransferasesBody compositionBody sizeBone mineralizationFTO proteinMouse model

Identifiers

PMID29203346
PMCPMC5798602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.