ArticleBiochemical and biophysical research communications2018
The splicing factor transformer2 (tra2) functions in the Drosophila fat body to regulate lipid storage.
Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- The regulation of carnitine palmitoyltransferase 1 (Biochemistry and biophysics reports · 2024Article
- The Role of Splicing Factors in Adipogenesis and Thermogenesis.Molecules and cells · 2023Review
- Review
- When does the female bias arise? Insights from the sex determination cascade of a flea beetle with a strongly skewed sex ratio.Functional & integrative genomics · 2023Article
- Transformer 2β regulates the alternative splicing of cell cycle regulatory genes to promote the malignant phenotype of ovarian cancer.Oncology research · 2023Article
- The regulation of lipid and carbohydrate storage by the splicing factor genemicroPublication biology · 2022Article
- The heterogeneous nuclear ribonucleoprotein (hnRNP) glorund functions in theBiochemistry and biophysics reports · 2021Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Excess nutrients are stored as triglycerides mainly in the adipose tissue of an animal and these triglycerides are located in structures called lipid droplets. Previous genome-wide RNAi screens in Drosophila cells identified splicing factors as playing a role in lipid droplet formation. Our lab has recently identified the SR protein, 9G8, as an important factor in fat storage as decreasing its levels results in augmented triglyceride storage in the fat body. Previous in vitro studies have implicated 9G8 in the regulation of splicing of the sex determination gene doublesex (dsx) by binding to transformer (tra) and transformer2 (tra2); however, any function of these sex determination proteins in regulating metabolism is unknown. In this study, we have uncovered a role of tra2 to regulate fat storage in vivo. Inducing tra2
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Registered trials
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