Evidence map›Paper›PMID 29203145›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2018

Global gene expression analysis of macrophage response induced by nonporous and porous silica nanoparticles.

Mostafa Yazdimamaghani, Philip J Moos, Hamidreza Ghandehari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  3. Journal of proteome research · 2025
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  7. New "Omics" Approaches as Tools to Explore Mechanistic Nanotoxicology.Advances in experimental medicine and biology · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Subchronic toxicity of silica nanoparticles as a function of size and porosity.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Article
  14. Genotoxicity of amorphous silica nanoparticles: Status and prospects.Nanomedicine : nanotechnology, biology, and medicine · 2019
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mostafa YazdimamaghaniUtah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA.
Philip J MoosUtah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA. Electronic address: philip.moos@utah.edu.
Hamidreza GhandehariUtah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT, USA; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA. Electronic address: hamid.ghandehari@utah.edu.
University of Utah · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
BIOLOGICAL FATE AND BIOCOMPATIBILITY OF SILICA-BASED NANOCONSTRUCTSR01ES024681 · NIEHS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Hamid Ghandehari · 2014 to 2026
$4.1M
NCI NIH HHS P30 CA042014NIEHS NIH HHS R01 ES024681
6 · The paper itself

Abstract

Little is known about the global gene expression profile of macrophages in response to changes in size and porosity of silica nanoparticles (SNPs). Spherical nonporous SNPs of two different diameters, and mesoporous spherical SNPs with comparable size were characterized. Reactive oxygen species, mitochondrial membrane potential, lysosome degradation capacity, and lysosome pH were measured to evaluate the influence of nonporous and mesoporous SNPs on mitochondrial and lysosomal function. RNA-sequencing was utilized to generate transcriptional profiles of RAW264.7 macrophages exposed to non-toxic SNP doses. DESeq2, limma, and BinReg2 software were used to analyze the data based on both unsupervised and supervised strategies to identify genes with greatest differences among NP treatments. Utilizing GATHER and DAVID software, possible induced pathways were studied. We found that mesoporous silica nanoparticles are capable of altering gene expression in macrophages at doses that do not elicit acute cytotoxicity, while gene transcription was minimally affected by nonporous SNPs.

Indexed as

Gene Expression ProfilingBiomarkersCells, CulturedCell SurvivalGene Expression RegulationHumansMacrophagesMembrane Potential, MitochondrialNanoparticlesPorosityReactive Oxygen SpeciesSilicon DioxideBiomarkersReactive Oxygen SpeciesSilicon DioxideGene expressionGene ontologyLysosome pathwayNanotoxicityReactive oxygen speciesSilica nanoparticles

Identifiers

PMID29203145
PMCPMC6050981
OpenAlexW2775552716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.