ArticlePhysiology & behavior2018
Using a memory systems lens to view the effects of estrogens on cognition: Implications for human health.
Article in Physiology & behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of estrogen on spatial navigation and memory.Psychopharmacology · 2024Trial
- Enhancement of response learning in male rats with intrastriatal infusions of a BDNF -TrkB agonist, 7,8-dihydroxyflavone.Behavioural brain research · 2026Article
- Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer's disease: three key timepoints through middle-age in females.Scientific reports · 2022Article
- Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats.Pharmacology, biochemistry, and behavior · 2022Article
- Extracellular levels of glucose in the hippocampus and striatum during maze training for food or water reward in male rats.Behavioural brain research · 2021Article
- Estradiol selectively regulates metabolic substrates across memory systems in models of menopause.Climacteric : the journal of the International Menopause Society · 2021Article
- Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause.Frontiers in pharmacology · 2021Review
- Aging is not equal across memory systems.Neurobiology of learning and memory · 2020Article
- Inactivation of the striatum in aged rats rescues their ability to learn a hippocampus-sensitive spatial navigation task.Neurobiology of learning and memory · 2020Article
- The Influence of Physical Activity and Epigenomics On Cognitive Function and Brain Health in Breast Cancer.Frontiers in aging neuroscience · 2020Review
- Involvement of lactate transport in two object recognition tasks that require either the hippocampus or striatum.Behavioral neuroscience · 2019Article
- Parkinson's Disease in Women and Men: What's the Difference?Journal of Parkinson's disease · 2019Review
- Licorice root components mimic estrogens in an object location task but not an object recognition task.Hormones and behavior · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the organizing and activating effects of gonadal steroids on adult physiology can guide insight into sex differences in and hormonal influences on health and disease, ranging from diabetes and other metabolic disorders, emotion and stress regulation, substance abuse, pain perception, immune function and inflammation, to cognitive function and dysfunction accompanying neurological disorders. Because the brain is highly sensitive to many forms of estrogens, it is not surprising that many adult behaviors, including cognitive function, are modulated by estrogens. Estrogens are known for their facilitating effects on learning and memory, but it is becoming increasingly clear that they also can impair learning and memory of some classes of tasks and may do so through direct actions on specific neural systems. This review takes a multiple memory systems approach to understanding how estrogens can at the same time enhance hippocampus-sensitive place learning and impair striatum-sensitive response learning by exploring the role estrogen receptor signaling may play in the opposing cognitive effects of estrogens. Accumulating evidence suggests that neither receptor subtype nor the timing of treatment, i.e. rapid vs slow, explain the bidirectional effects of estrogens on different types of learning. New findings pointing to neural metabolism and the provision of energy substrates by astrocytes as a candidate mechanism for cognitive enhancement and impairment are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.