ArticleVeterinary research2017
Gene expression in the chicken caecum is dependent on microbiota composition.
Article in Veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Threats and Opportunities When Using Chickens as a Model for Host-Microbiota Studies.Microorganisms · 2026Review
- Transcriptomic Analysis of Gene Expression Patterns in the Cecal Tissue of Liangshan Yanying Chickens and Arbor Acres (AA) Chickens Before 28 Days of Age.Animals : an open access journal from MDPI · 2026Article
- Modulatory effects of in ovo delivery of galactooligosaccharide and Lactiplantibacillus plantarum on antioxidant capacity, gene expression, and selected plasma metabolite parameters of broiler chickens.Journal of applied genetics · 2025Article
- Immunoglobulin secretion influences the composition of chicken caecal microbiota.Scientific reports · 2024Article
- Effects ofHeliyon · 2023Article
- Article
- Role of Physiology, Immunity, Microbiota, and Infectious Diseases in the Gut Health of Poultry.Vaccines · 2022Review
- Novel strategies to improve chicken performance and welfare by unveiling host-microbiota interactions through hologenomics.Frontiers in physiology · 2022Article
- Detoxification, Hydrogen Sulphide Metabolism and Wound Healing Are the Main Functions That Differentiate Caecum Protein Expression from Ileum of Week-Old Chicken.Animals : an open access journal from MDPI · 2021Article
- Early-Life Immune System Maturation in Chickens Using a Synthetic Community of Cultured Gut Bacteria.mSystems · 2021Article
- Limited influence of the microbiome on the transcriptional profile of female Aedes aegypti mosquitoes.Scientific reports · 2020Article
- Impact of galactooligosaccharides delivered in ovo on mitigating negative effects of heat stress on performance and welfare of broilers.Poultry science · 2020Article
- Exploring Differential Transcriptome between Jejunal and Cecal Tissue of Broiler Chickens.Animals : an open access journal from MDPI · 2019Article
- Modulation of microbial communities and mucosal gene expression in chicken intestines after galactooligosaccharides delivery In Ovo.PloS one · 2019Article
- Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gut microbiota is of considerable importance for each host. Despite this, germ-free animals can be obtained and raised to sexual maturity and consequences of the presence or absence of gut microbiota on gene expression of the host remain uncharacterised. In this study, we performed an unbiased study of protein expression in the caecum of germ-free and colonised chickens. The major difference between these two groups was in the expression of immunoglobulins which were essentially absent in the germ-free chickens. Microbiota also caused a minor decrease in the expression of focal adhesion and extracellular matrix proteins and an increase in the expression of argininosuccinate synthase ASS1, redox potential sensing, fermentative metabolic processes and detoxification systems represented by sulfotransferases SULT1C3 or SULT1E1. Since we also analysed expression in the caecum of E. coli Nissle and E. faecium DSM7134 mono-associated chickens, we concluded that at least immunoglobulin expression and expression of cystathionine synthase (CBS) was dependent on microbiota composition with E. coli Nissle stimulating more immunoglobulin and PIGR expression and E. faecium DSM7134 stimulating more CBS expression. Gut microbiota and its composition therefore affected protein expression in the chicken caecum though except for immunoglobulin production, the remaining differences were unexpectedly low.
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