ArticleBMC genomics2017
Genetic diversity and association mapping of mineral element concentrations in spinach leaves.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Reconfiguring biofortification strategies to transform food systems and address micronutrient deficiency of the 21st century.Journal of integrative plant biology · 2026Review
- Genome-wide association and genomic prediction of anthracnose (Colletotrichum dematium) resistance in spinach.The plant genome · 2026Article
- Spinach (Foods (Basel, Switzerland) · 2025Article
- Association between trace metal element levels and ideal cardiovascular health in adolescents.European journal of medical research · 2025Article
- Integration of crop modeling and sensing into molecular breeding for nutritional quality and stress tolerance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Improving genomic prediction of vitamin C content in spinach using GWAS-derived markers.BMC genomics · 2025Article
- A comprehensive UHPLC-MS/MS and extraction method reveals flavonoid profile and concentration are diverse in spinach (Frontiers in plant science · 2025Article
- A Genome-Wide Association Study Reveals the Genetic Mechanisms of Nutrient Accumulation in Spinach.Genes · 2024Article
- Improvement of crop production in controlled environment agriculture through breeding.Frontiers in plant science · 2024Review
- Vegetables with Enhanced Iron Bioavailability-German Consumers' Perceptions of a New Approach to Improve Dietary Iron Supply.Nutrients · 2023Article
- Identifying the Genetic Basis of Mineral Elements in Rice Grain Using Genome-Wide Association Mapping.Genes · 2022Article
- Effects of Wet and Dry Micronization on the GC-MS Identification of the Phenolic Compounds and Antioxidant Properties of Freeze-Dried Spinach Leaves and Stems.Molecules (Basel, Switzerland) · 2022Article
- Applications of Genomic Tools in Plant Breeding: Crop Biofortification.International journal of molecular sciences · 2022Review
- Identification of quantitative trait loci (QTLs) and candidate genes of seed Iron and zinc content in soybean [Glycine max (L.) Merr.].BMC genomics · 2022Article
- Genome-wide association study and genomic prediction of white rust resistance in USDA GRIN spinach germplasm.Horticulture research · 2022Article
- Potato biofortification: an effective way to fight global hidden hunger.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Review
- Expression profiling of the Dof gene family under abiotic stresses in spinach.Scientific reports · 2021Article
- An anchored chromosome-scale genome assembly of spinach improves annotation and reveals extensive gene rearrangements in euasterids.The plant genome · 2021Article
- High resolution mapping and candidate gene identification of downy mildew race 16 resistance in spinach.BMC genomics · 2021Article
- Phenotypic Diversity and Association Mapping of Ascorbic Acid Content in Spinach.Frontiers in genetics · 2021Article
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9 authors.
Funding
Abstract
backgroundSpinach is a useful source of dietary vitamins and mineral elements. Breeding new spinach cultivars with high nutritional value is one of the main goals in spinach breeding programs worldwide, and identification of single nucleotide polymorphism (SNP) markers for mineral element concentrations is necessary to support spinach molecular breeding. The purpose of this study was to conduct a genome-wide association study (GWAS) and to identify SNP markers associated with mineral elements in the USDA-GRIN spinach germplasm collection.
resultsA total of 14 mineral elements: boron (B), calcium (Ca), cobalt (Co), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), manganese (Mn), molybdenum (Mo), sodium (Na), nickel (Ni), phosphorus (P), sulfur (S), and zinc (Zn) were evaluated in 292 spinach accessions originally collected from 29 countries. Significant genetic variations were found among the tested genotypes as evidenced by the 2 to 42 times difference in mineral concentrations. A total of 2402 SNPs identified from genotyping by sequencing (GBS) approach were used for genetic diversity and GWAS. Six statistical methods were used for association analysis. Forty-five SNP markers were identified to be strongly associated with the concentrations of 13 mineral elements. Only two weakly associated SNP markers were associated with K concentration. Co-localized SNPs for different elemental concentrations were discovered in this research. Three SNP markers, AYZV02017731_40, AYZV02094133_57, and AYZV02281036_185 were identified to be associated with concentrations of four mineral components, Co, Mn, S, and Zn. There is a high validating correlation coefficient with r > 0.7 among concentrations of the four elements. Thirty-one spinach accessions, which rank in the top three highest concentrations in each of the 14 mineral elements, were identified as potential parents for spinach breeding programs in the future.
conclusionsThe 45 SNP markers strongly associated with the concentrations of the 13 mineral elements: B, Ca, Co, Cu, Fe, Mg, Mn, Mo, Na, Ni, P, S, and Zn could be used in breeding programs to improve the nutritional quality of spinach through marker-assisted selection (MAS). The 31 spinach accessions with high concentrations of one to several mineral elements can be used as potential parents for spinach breeding programs.
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