Evidence map›Paper›PMID 29202640›Full record

ArticleJournal of dental research2018

A Comparative Assessment of Implant Site Viability in Humans and Rats.

C-H Chen, X Pei, U S Tulu, M Aghvami, C-T Chen, D Gaudillière, M Arioka, M Maghazeh Moghim, O Bahat, M Kolinski and 4 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

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  15. In vivo performance of AlJournal of orthopaedic surgery and research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 6 countries.

C-H Chen1 Craniofacial Research Center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan.
X Pei2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
U S Tulu2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
M Aghvami2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
C-T Chen1 Craniofacial Research Center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan.
D Gaudillière2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
M Arioka2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
M Maghazeh Moghim2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
O Bahat7 Private practice, Beverly Hills, CA, USA.
M Kolinski8 Private practice, St. Charles, IL, USA.
T R Crosby8 Private practice, St. Charles, IL, USA.
A Felderhoff9 Private practice, Munich, Germany.
J B Brunski2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
J A Helms2 Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · USSt. Charles Hospital · USBeverly Hills Cancer Center · USChang Gung University · TWKeelung Chang Gung Memorial Hospital · TWMunich Business School · DESichuan University · CN

Funding

Mechanobiology at Healing Bone-Implant InterfacesR01DE024000 · NIDCR · STANFORD UNIVERSITY · PI BRUNSKI, JOHN BEYER, HELMS, JILL A · 2014 to 2018
$3.4M
NIDCR NIH HHS R01 DE024000
6 · The paper itself

Abstract

Our long-term objective is to devise methods to improve osteotomy site preparation and, in doing so, facilitate implant osseointegration. As a first step in this process, we developed a standardized oral osteotomy model in ovariectomized rats. There were 2 unique features to this model: first, the rats exhibited an osteopenic phenotype, reminiscent of the bone health that has been reported for the average dental implant patient population. Second, osteotomies were produced in healed tooth extraction sites and therefore represented the placement of most implants in patients. Commercially available drills were then used to produce osteotomies in a patient cohort and in the rat model. Molecular, cellular, and histologic analyses demonstrated a close alignment between the responses of human and rodent alveolar bone to osteotomy site preparation. Most notably in both patients and rats, all drilling tools created a zone of dead and dying osteocytes around the osteotomy. In rat tissues, which could be collected at multiple time points after osteotomy, the fate of the dead alveolar bone was followed. Over the course of a week, osteoclast activity was responsible for resorbing the necrotic bone, which in turn stimulated the deposition of a new bone matrix by osteoblasts. Collectively, these analyses support the use of an ovariectomy surgery rat model to gain insights into the response of human bone to osteotomy site preparation. The data also suggest that reducing the zone of osteocyte death will improve osteotomy site viability, leading to faster new bone formation around implants.

Indexed as

Dental ImplantsAdultAgedAged, 80 and overAnimalsCone-Beam Computed TomographyDental Implantation, EndosseousFemaleFemurFinite Element AnalysisHumansImplants, ExperimentalMaleMiddle AgedModels, AnimalMolarDental Implantsbonecomputer modeldrillosteogenesisosteotomyovariectomy

Identifiers

PMID29202640
PMCPMC5863872
OpenAlexW2771156905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.