ArticleJournal of proteome research2018
Poisson Model To Generate Isotope Distribution for Biomolecules.
Article in Journal of proteome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- A Computational Model for Determining Labeling Duration in Protein Turnover Studies Using a Single Deuterated Water Labeled Sample.Journal of the American Society for Mass Spectrometry · 2026Article
- FAST MS: Software for the Automated Analysis of Top-Down Mass Spectra of Polymeric Molecules Including RNA, DNA, and Proteins.Journal of the American Society for Mass Spectrometry · 2025Article
- Numbers of Exchangeable Hydrogens from LC-MS Data of Heavy Water Metabolically Labeled Samples.Journal of the American Society for Mass Spectrometry · 2024Article
- Metabolomic and proteomic applications to exercise biomedicine.Translational exercise biomedicine · 2024Review
- Flexible Quality Control for Protein Turnover Rates Using d2ome.International journal of molecular sciences · 2023Article
- A large-scale LC-MS dataset of murine liver proteome from time course of heavy water metabolic labeling.Scientific data · 2023Article
- OligoR: A Native HDX/MS Data Processing Application Dedicated to Oligonucleotides.Analytical chemistry · 2023Article
- Low-dose ethanol increases aflatoxin production due to theiScience · 2023Article
- Protein turnover models for LC-MS data of heavy water metabolic labeling.Briefings in bioinformatics · 2022Article
- Mammary Development in Gilts at One Week Postnatal Is Related to Plasma Lysine Concentration at 24 h after Birth, but Not Colostrum Dose.Animals : an open access journal from MDPI · 2021Article
- Proteome Dynamics from Heavy Water Metabolic Labeling and Peptide Tandem Mass Spectrometry.International journal of mass spectrometry · 2019Article
- d2ome, Software for in Vivo Protein Turnover Analysis Using Heavy Water Labeling and LC-MS, Reveals Alterations of Hepatic Proteome Dynamics in a Mouse Model of NAFLD.Journal of proteome research · 2018Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
We introduce a simplified computational algorithm for computing isotope distributions (relative abundances and masses) of biomolecules. The algorithm is based on Poisson approximation to binomial and multinomial distributions. It leads to a small number of arithmetic operations to compute isotope distributions of molecules. The approach uses three embedded loops to compute the isotope distributions, as compared with the eight embedded loops in exact calculations. The speed improvement is about 3-fold compared to the fast Fourier transformation-based isotope calculations, often termed as ultrafast isotope calculation. The approach naturally incorporates the determination of the masses of each molecular isotopomer. It is applicable to high mass accuracy and resolution mass spectrometry data. The application to tryptic peptides in a UniProt protein database revealed that the mass accuracy of the computed isotopomers is better than 1 ppm. Even better mass accuracy (below 1 ppm) is achievable when the method is paired with the exact calculations, which we term a hybrid approach. The algorithms have been implemented in a freely available C/C++ code.
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