Evidence map›Paper›PMID 29202327›Full record

ReviewCurrent opinion in neurobiology2018

Mesh electronics: a new paradigm for tissue-like brain probes.

Guosong Hong, Xiao Yang, Tao Zhou, Charles M Lieber

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 159 citations in OpenAlex.

  1. Article
  2. Review
  3. Soft, Flexible, and Stretchable Platforms for Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Chronic recording of brain activity in awake toads.Journal of neuroscience methods · 2025
    Article
  9. Review
  10. Atomically thin bioelectronics.Nature reviews. Materials · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Review
  18. Stitching Flexible Electronics into the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  19. Review
  20. Failure Reason of PI Test Samples of Neural Implants.Sensors (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guosong HongDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Xiao YangDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Tao ZhouDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Charles M LieberDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Electronic address: cml@cmliris.harvard.edu.
Harvard University · US

Funding

Syringe-Injectable Mesh Electronics for Seamless Integration with the Central Nervous SystemDP1EB025835 · NIBIB · HARVARD UNIVERSITY · PI LIEBER, CHARLES M · 2017 to 2019
$3.5M
Syringe Injectable Electronics Platform for Chronic Mapping and Modulation of Neural Circuits in AddictionR21DA043985 · NIDA · HARVARD UNIVERSITY · PI LIEBER, CHARLES M · 2017 to 2018
$436k
Brain Aging Studies with Single-Neuron Resolution Using Syringe-Injectable ElectronicsK99AG056636 · NIA · HARVARD UNIVERSITY · PI HONG, GUOSONG · 2017 to 2018
$255k
NIA NIH HHS K99 AG056636NIBIB NIH HHS DP1 EB025835NIDA NIH HHS R21 DA043985
6 · The paper itself

Abstract

Existing implantable neurotechnologies for understanding the brain and treating neurological diseases have intrinsic properties that have limited their capability to achieve chronically-stable brain interfaces with single-neuron spatiotemporal resolution. These limitations reflect what has been dichotomy between the structure and mechanical properties of living brain tissue and non-living neural probes. To bridge the gap between neural and electronic networks, we have introduced the new concept of mesh electronics probes designed with structural and mechanical properties such that the implant begins to 'look and behave' like neural tissue. Syringe-implanted mesh electronics have led to the realization of probes that are neuro-attractive and free of the chronic immune response, as well as capable of stable long-term mapping and modulation of brain activity at the single-neuron level. This review provides a historical overview of a 10-year development of mesh electronics by highlighting the tissue-like design, syringe-assisted delivery, seamless neural tissue integration, and single-neuron level chronic recording stability of mesh electronics. We also offer insights on unique near-term opportunities and future directions for neuroscience and neurology that now are available or expected for mesh electronics neurotechnologies.

Indexed as

AnimalsBrainElectronicsHumansNeurons

Identifiers

PMID29202327
PMCPMC5984112
OpenAlexW2771797278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.