ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Aberrant Temporal Connectivity in Persons at Clinical High Risk for Psychosis.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin.Molecular psychiatry · 2024Trial
- Linking speech patterns to brain structure in affective and psychotic disorders: an integrative natural language processing approach.Molecular psychiatry · 2026Article
- Latent Growth Models of Longitudinal Changes in Functional Connectivity during Early Stage Psychosis.Neuroinformatics · 2025Article
- The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Multimodal fusion of brain signals for robust prediction of psychosis transition.Schizophrenia (Heidelberg, Germany) · 2024Article
- 3M_BANTOR: A regression framework for multitask and multisession brain network distance metrics.Network neuroscience (Cambridge, Mass.) · 2023Article
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study.Frontiers in neuroscience · 2022Article
- Cerebellar correlates of social dysfunction among individuals at clinical high risk for psychosis.Frontiers in psychiatry · 2022Article
- Characterizing effects of age, sex and psychosis symptoms on thalamocortical functional connectivity in youth.NeuroImage · 2021Article
- Neuroimaging Markers of Resiliency in Youth at Clinical High Risk for Psychosis: A Qualitative Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Identification of common neural substrates with connectomic abnormalities in four major psychiatric disorders: A connectome-wide association study.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Language as a biomarker for psychosis: A natural language processing approach.Schizophrenia research · 2020Review
- Altered resting-state functional connectivity in young children at familial high risk for psychotic illness: A preliminary study.Schizophrenia research · 2020Article
- A cross-disorder connectome landscape of brain dysconnectivity.Nature reviews. Neuroscience · 2019Review
- Hierarchical deficits in auditory information processing in schizophrenia.Schizophrenia research · 2019Article
- Emerging Temporal Lobe Dysfunction in People at Clinical High Risk for Psychosis.Frontiers in psychiatry · 2019Review
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundSchizophrenia, a neurodevelopmental disorder, involves abnormalities in functional connectivity (FC) across distributed neural networks, which are thought to antedate the emergence of psychosis. In a cohort of adolescents and young adults at clinical high risk (CHR) for psychosis, we applied data-driven approaches to resting-state fMRI data so as to systematically characterize FC abnormalities during this period and determine whether these abnormalities are associated with psychosis risk and severity of psychotic symptoms.
methodsFifty-one CHR participants and 47 matched healthy controls (HCs) were included in our analyses. Twelve of these CHR participants developed psychosis within 3.9 years. We estimated one multivariate measure of FC and studied its relationship to CHR status, conversion to psychosis and positive symptom severity.
resultsMultivariate analyses revealed between-group differences in whole-brain connectivity patterns of bilateral temporal areas, mostly affecting their functional connections to the thalamus. Further, more severe positive symptoms were associated with greater connectivity abnormalities in the anterior cingulate and frontal cortex.
conclusionsOur study demonstrates that the well-established FC abnormalities of the thalamus and temporal areas observed in schizophrenia are also present in the CHR period, with aberrant connectivity of the temporal cortex most associated with psychosis risk.
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