Evidence map›Paper›PMID 29201992›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017

Probability of Alzheimer's disease in breast cancer survivors based on gray-matter structural network efficiency.

Shelli R Kesler, Vikram Rao, William J Ray, Arvind Rao, Alzheimer's Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Seeing through "brain fog": neuroimaging assessment and imaging biomarkers for cancer-related cognitive impairments.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  6. Article
  7. Article
  8. aXonica: A support package for MRI based Neuroimaging.Biotechnology notes (Amsterdam, Netherlands) · 2024
    Article
  9. Review
  10. Review
  11. Chemobrain: An accelerated aging process linking adenosine AInternational review of neurobiology · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Protective Effects ofJNCI cancer spectrum · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shelli R KeslerDepartment of Neuro-oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Vikram RaoDepartment of Neuro-oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
William J RayThe Neurodegeneration Consortium at the Institute of Applied Cancer Science, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Arvind RaoDepartment of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)R01CA172145 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KESLER, SHELLI R, PALESH, OXANA G · 2012 to 2024
$3.3M
Multimodal MRI Biomarker of Mild Cognitive Impairment in Breast CancerR01NR014195 · NINR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KESLER, SHELLI R, WEFEL, JEFFREY SCOTT · 2012 to 2017
$2.5M
Machine Learning Comparison of Brain Anatomy in Cancer and Alzheimer's DiseaseR03CA191559 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KESLER, SHELLI R · 2015 to 2016
$160k
NCI NIH HHS R01 CA172145NCI NIH HHS R03 CA191559NIA NIH HHS U01 AG024904NINR NIH HHS R01 NR014195
6 · The paper itself

Abstract

introductionBreast cancer chemotherapy is associated with accelerated aging and potentially increased risk for Alzheimer's disease (AD).

methodsWe calculated the probability of AD diagnosis from brain network and demographic and genetic data obtained from 47 female AD converters and 47 matched healthy controls. We then applied this algorithm to data from 78 breast cancer survivors.

resultsThe classifier discriminated between AD and healthy controls with 86% accuracy ( DISCUSSION: Chemotherapy-treated breast cancer survivors who have a particular profile of brain structure may have a higher risk for AD, especially those who are older and have lower cognitive reserve.

Indexed as

Alzheimer's diseaseBreast cancerChemotherapyConnectomeMRI

Identifiers

PMID29201992
PMCPMC5700833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.