Evidence map›Paper›PMID 29201961›Full record

ArticleEmergency (Tehran, Iran)2017

Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial.

Hassan Barzegari, Hassan Motamed, Behrad Ziapour, Majid Hajimohammadi, Mina Kadkhodazadeh

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Emergency (Tehran, Iran), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03576820 (Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03576820 phase3unknown statusnot on this mapstarted 2018, after this paper: background citation

Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department

TypeinterventionalSponsorNew York City Health and Hospitals CorporationRan2018 to 2022Enrolled50ConditionsMigraineArmsLidocaine, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hassan BarzegariEmergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Hassan MotamedEmergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Behrad ZiapourEmergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Majid HajimohammadiEmergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mina KadkhodazadehEmergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ahvaz Jundishapur University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMost of the headache cases only require pain management in emergency department (ED). The present study aimed to evaluate the efficacy of intranasal lidocaine in this regard.

methodIn this clinical trial, adult patients with primary headache were randomly treated with 7.5 mg intravenous (IV) chlorpromazine and 1 ml intranasal lidocaine 2% (treatment) or normal saline 0.9% (placebo), and were compared 5, 15, and 30 minutes later regarding success rate using SPSS 21.

result100 patients were assigned to either treatment or placebo group. Number needed to treat of intranasal lidocaine at 5, 15, and 30 minutes were 4 (95% CI: 2.2 - 6.6), 3 (95% CI: 1.7 - 3.5), and 4 (95% CI: 2.3 - 15.9), respectively. These measures for absolute risk reduction were 30 (95% CI: 15.2 - 44.8), 44 (95% CI: 28.7 - 59.3), and 26 percent (95% CI: 6.3 - 44.3), respectively. Pain relapse occurred in 16% of treatment and 11% of control group within 1 hour of treatment (p = 0.402).

conclusionIt seems that, intranasal lidocaine along with IV chlorpromazine could result in more successful and faster management of primary headaches in ED.

Indexed as

administrationintranasallidocainemigraine disordersPain managementtension-type Headache

Identifiers

PMID29201961
PMCPMC5703756
OpenAlexW2754668474

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.