ArticleAnnals of translational medicine2017
Factors that influence blood loss and need for transfusion following total knee arthroplasty.
Article in Annals of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness and safety of the use of antifibrinolytic agents in total-knee arthroplasty: A meta-analysis.Medicine · 2020Pooled it
- Role of Suction Drain after Knee Arthroplasty in the Tranexamic Acid Era: A Randomized Controlled Study.Clinics in orthopedic surgery · 2019Trial
- Interpretable Machine Learning Analysis of Factors Associated with Postoperative Hemoglobin Reduction After Total Knee Arthroplasty: A Standardized-Protocol Cohort Study in Non-Transfused Patients.Journal of clinical medicine · 2026Article
- Towards rational blood utilization: development of a transfusion risk prediction tool for onco-surgical practice.World journal of surgical oncology · 2026Article
- Routine post-operative full blood count assessment is not necessary in elective hip and knee arthroplasty: A prospective cohort study.Journal of clinical orthopaedics and trauma · 2025Article
- Prevalence of Blood Transfusion and Factors Influencing Blood Loss Following Primary Total Knee Replacement Surgery.Malaysian orthopaedic journal · 2025Article
- Comparative Efficacy and Safety of Intravenous vs. Combined Intravenous and Intraarticular Tranexamic Acid Administration in Total Knee Arthroplasty: A Stratified Analysis Based on Bleeding Risk.The archives of bone and joint surgery · 2025Article
- Article
- Risk factor analysis and establishment of a nomogram model to predict blood loss during total knee arthroplasty.BMC musculoskeletal disorders · 2024Article
- Cardiac interventions on total knee arthroplasty: a national inpatient sample-based analysis.Archives of orthopaedic and trauma surgery · 2024Article
- Cardiovascular Disease in Total Knee Arthroplasty: An Analysis of Hospital Outcomes, Complications, and Mortality.Clinics in orthopedic surgery · 2024Article
- Optimal Release Timing of Drain Clamping to Reduce Postoperative Bleeding after Total Knee Arthroplasty with Intraarticular Injection of Tranexamic Acid.Medicina (Kaunas, Lithuania) · 2022Article
- Perioperative blood transfusions in hip and knee arthroplasty: a retrospective assessment of combined risk factors.Archives of orthopaedic and trauma surgery · 2022Article
- Are Risk Factors for Postoperative Significant Hemorrhage following Total Knee Arthroplasty Potentially Modifiable? A Retrospective Cohort Study.Journal of personalized medicine · 2022Article
- The effects of a new protocol on blood loss in total knee arthroplasty.Orthopedic reviews · 2022Article
- Is Routine Hemoglobin Monitoring Necessary after Elective Hip and Knee Arthroplasty?Arthroplasty today · 2020Article
- One-staged combined hip and knee arthroplasty: retrospective comparative study at mid-term follow-up.Journal of orthopaedic surgery and research · 2019Article
- The incidence and risk factors for allogenic blood transfusion in total knee and hip arthroplasty.Journal of orthopaedic surgery and research · 2019Observational
- An insight into the utilization of allogenic blood transfusion and factors affecting blood transfusion in total knee replacement surgery in a tertiary care hospital in Eastern India.Asian journal of transfusion scienceArticle
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood loss during total knee arthroplasty (TKA) remains a concern, as many patients require blood transfusions, which increase risks of allergic reactions, disease transmission, and thromboembolisms. The purpose was to determine factors associated with blood loss and need for transfusion in patients receiving routine TKA.
methodsThe authors prospectively analyzed 150 consecutive uncemented TKAs for age, gender, body mass index (BMI), anticoagulant medication, type of anesthesia, tranexamic acid (TXA) administration, tourniquet inflation, drain placement, pre- and post-operative Haemoglobin (Hb) level (g/dL), and whether transfusion was necessary. Univariable and multivariable regression analyses were performed to identify factors associated with Hb loss and need for transfusion with significance level set at P value<0.05.
resultsThe cohort comprised 92 women and 58 men, aged 69.5±8.9 years. The mean Hb loss was 3.7±1.3 g/dL. The 20 patients (13%) who had transfusions also had lower preoperative Hb (12.6±1.2 g/dL) compared to the remaining patients (14.3±1.2 g/dL). Hb loss was significantly associated with preoperative Hb, TXA, and gender, but multivariable regression identified gender as a confounder and indicated that TXA reduced Hb loss by 0.92 g/dL. Multivariable regression revealed the need for transfusion was only significantly associated with preoperative Hb and indicated that a decrease of preoperative Hb by 1 g/dL nearly quadrupled the chances of needing transfusion.
conclusionsHb loss was significantly associated with preoperative Hb levels and use of TXA, while the need for transfusion was only associated with preoperative Hb levels. These findings could help identify patients at risk for blood transfusions. Level of evidence: level III, prospective case series.
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