ArticleNeuroImage. Clinical2018
The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium.Human brain mapping · 2022Pooled it
- A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.Human brain mapping · 2022Pooled it
- Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- The role of the globus pallidus subregions in the schizophrenia spectrum continuum.Molecular psychiatry · 2026Article
- Distinct subcortical neuroanatomic profiles of treatment-resistant schizophrenia: structural magnetic resonance imaging study.BJPsych open · 2026Article
- ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders.Neuropsychopharmacology reports · 2025Article
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.Molecular psychiatry · 2023Article
- Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia.BMC medicine · 2023Article
- Facial emotion perception abilities are related to grey matter volume in the culmen of cerebellum anterior lobe in drug-naïve patients with first-episode schizophrenia.Brain imaging and behavior · 2022Article
- Neuroimaging at 7 Tesla: a pictorial narrative review.Quantitative imaging in medicine and surgery · 2022Review
- Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes.NeuroImage. Clinical · 2022Article
- Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA.Human brain mapping · 2022Review
- Trends in big data analyses by multicenter collaborative translational research in psychiatry.Psychiatry and clinical neurosciences · 2022Review
- Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum.Schizophrenia bulletin · 2021Article
- Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study.Journal of personalized medicine · 2021Article
- Relationships Among Retinal Nerve Fiber Layer Thickness, Vascular Endothelial Growth Factor, and Cognitive Impairment in Patients with Schizophrenia.Neuropsychiatric disease and treatment · 2021Article
- Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State.Schizophrenia bulletin · 2020Article
- Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
27 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis.
methodsImaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept. The statistical significance of fixed-effect of dependent variable was assessed.
resultsDaily dose of antipsychotics was positively associated with left globus pallidus volume and negatively associated with right hippocampus. It was also positively associated with laterality index of globus pallidus. Duration of illness was positively associated with bilateral globus pallidus volumes. Type of antipsychotics did not have any effect on the subcortical volumes. DISCUSSION: A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication.
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