ReviewCurrent behavioral neuroscience reports2017
Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson's Disease.
Review in Current behavioral neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Targeting TREM2 for Parkinson's Disease: Where to Go?Frontiers in immunology · 2021Pooled it
- Micro- and nanoplastics as environmental modifiers of neuroimmune dysfunction in Parkinson's disease.Frontiers in neuroscience · 2026Review
- Anxiolytic effects of Enterococcus faecalis 2001 on a mouse model of colitis.Scientific reports · 2024Article
- Editorial: Gut microbiota as a therapeutic target in neuropsychiatric disorders: current status and future directions.Frontiers in neuroscience · 2023Article
- Differences in the Composition of Gut Microbiota between Patients with Parkinson's Disease and Healthy Controls: A Cohort Study.Journal of clinical medicine · 2021Article
- Review
- Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin.Advances in nutrition (Bethesda, Md.) · 2021Article
- What Is Our Understanding of the Influence of Gut Microbiota on the Pathophysiology of Parkinson's Disease?Frontiers in neuroscience · 2021Review
- The Contribution of Gut Microbiota-Brain Axis in the Development of Brain Disorders.Frontiers in neuroscience · 2021Review
- Association of Parkinson's Disease With Microbes and Microbiological Therapy.Frontiers in cellular and infection microbiology · 2021Review
- Dysregulation of the Gut-Brain Axis, Dysbiosis and Influence of Numerous Factors on Gut Microbiota Associated Parkinson's Disease.Current neuropharmacology · 2021Review
- Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease.Biomolecules · 2020Review
- Parkinson's disease and the gastrointestinal microbiome.Journal of neurology · 2020Review
- Effects of the probiotic formulation SLAB51 inAging · 2020Article
- Parkinson's Disease and the Gut: Future Perspectives for Early Diagnosis.Frontiers in neuroscience · 2020Review
- Olfactory Dysfunction and Its Relationship With Clinical Features of Parkinson's Disease.Frontiers in neurology · 2020Article
- Escherichia coli Clonobiome: Assessing the Strain Diversity in Feces and Urine by Deep Amplicon Sequencing.Applied and environmental microbiology · 2019Article
- Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain-gut axis.Journal of neuroinflammation · 2019Article
- Health Benefits of Nut Consumption in Middle-Aged and Elderly Population.Antioxidants (Basel, Switzerland) · 2019Review
- Stress co-opts the gut to affect epileptogenesis. Commentary on "Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome".Epilepsia open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewPatients suffering from Parkinson's disease (PD) are known to experience gastrointestinal dysfunction that might precede the onset of motor symptoms by several years. Evidence suggests an important role of the gut-brain axis in PD pathogenesis. These interactions might be essentially influenced by the gut microbiota. Here, we review recent findings supporting that changes in the gut microbiota composition might be a trigger for inflammation contributing to neurodegeneration in PD. RECENT
findingsRecent research revealed that PD patients exhibit a pro-inflammatory microbiota profile in their intestinal tract that might increase gut permeability, allowing leakage of bacterial products and inflammatory mediators from the intestines. Evidence in literature indicates that alpha-synuclein deposition might start in the enteric nervous system by pro-inflammatory immune activity and then propagates to the CNS. Alternatively, the peripheral inflammatory response could impact the brain through systemic mechanisms. SUMMARY: A better understanding of the gut-brain interactions and the role of the intestinal microbiota in the regulation of immune responses might bring new insights in PD pathological progression and might lead to novel diagnostics and therapeutic approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.