ArticleCaspian journal of internal medicine2017
Does the low-density lipoprotein cholesterol play a key role in predicting metabolic syndrome in the Iranian adult population?
Article in Caspian journal of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Transitioning from having no metabolic abnormality nor obesity to metabolic impairment in a cohort of apparently healthy adults.Cardiovascular diabetology · 2023Article
- Lipid accumulation product is a better predictor of metabolic syndrome in Chinese adolescents: a cross-sectional study.Frontiers in endocrinology · 2023Article
- Association between serum low-density lipoprotein cholesterol and metabolic syndrome in a working population.Lipids in health and disease · 2021Article
- Triglyceride to high-density lipoprotein cholesterol and low-density lipoprotein cholestrol to high-density lipoprotein cholesterol ratios are predictors of cardiovascular risk in Iranian adults: Evidence from a population-based cross-sectional study.Caspian journal of internal medicine · 2020Article
- Identification of Traditional Chinese Medicine Constitutions and Physiological Indexes Risk Factors in Metabolic Syndrome: A Data Mining Approach.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Metabolic syndrome and different obesity phenotypes in the elderly women population: Iran's Health System on aging.Caspian journal of internal medicine · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe low density lipoprotein cholestrol (LDL-C) has an important role in the pathogenesis of cardiovascular disease but its association and predictive accuracy with metabolic syndrome (MetS) remains controversial. The objective of this study was to investigate the association and predictive ability of LDL-C with MetS.
methodsWe analyzed the data from a population-based cross-sectional study conducted on representative samples of an Iranian adult population. The demographic data, anthropometric measures and the lipid profiles were measured with standard methods, and MetS was diagnosed by ATP III criteria. Logistic regression model and ROC analysis were used to estimate the predictive accuracy of LDL-C and its association with MetS.
resultsThe mean age (±SD) of participants with and without MetS was 47.6±12.5 years and 39.1±12.9 years, respectively (p=0.001). All anthropometric measures (body mass index, waist circumference, waist to hip ratio, waist to height ratio), systolic blood pressure, total cholesterol, triglycerides and fasting blood glucose were significantly higher in MetS, but a significantly higher difference in LDL-C was observed only in women. Accuracy of LDL-C in predicting MetS for men and women was 0.48 (95% CI: 0.43-0.54) and 0.55 (95% CI: 0.51-0.60), respectively. The unadjusted and adjusted odds ratios of different quartiles of LDL-C compared with 1
conclusionSerum LDL-C level is not significantly associated with MetS but exhibits a weak ability in predicting MetS in women.
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