ArticleCaspian journal of internal medicine2017
Potential drug-drug interactions among hospitalized patients in a developing country.
Article in Caspian journal of internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Drug-drug interaction among elderly patients in Africa: a systematic review and meta-analysis.BMC pharmacology & toxicology · 2025Pooled it
- Prevalence of potential drug‒drug interactions and associated factors among elderly patients in Ethiopia: a systematic review and meta-analysis.Global health research and policy · 2024Pooled it
- Prevalence of clinically manifested drug interactions in hospitalized patients: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Evaluation of pharmacokinetic interactions of amoxicillin with ranitidine in healthy human volunteers of Karachi, Pakistan.PloS one · 2022Trial
- Potential drug-drug interactions among hospitalised cardiac patients in Nepal: a prospective observational study.BMJ open · 2025Observational
- Opioid metabolism and drug-drug interaction in cancer.The oncologist · 2024Review
- Possible drug-drug interactions among elderly patients receiving antiviral therapy for chronic hepatitis B.Croatian medical journal · 2024Article
- Accurate prediction of drug combination risk levels based on relational graph convolutional network and multi-head attention.Journal of translational medicine · 2024Article
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- The Prevalence and Severity of Potential Drug-Drug Interactions in Internal Medicine Ward at Soba Teaching Hospital.Drug, healthcare and patient safety · 2023Article
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- Potential Drug Interactions in Adults Living in Manaus: A Real-World Comparison of Two Databases, 2019.Turkish journal of pharmaceutical sciences · 2022Article
- Potential Drug-Drug Interactions in a Cardiac Center: Development of Simple Software for Pattern Identification.The journal of Tehran Heart Center · 2022Article
- Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy.Advances in therapy · 2022Review
- A retrospective evaluation of drug-drug interactions in patients admitted to Internal Medicine Departments in Palestinian Hospitals.SAGE open medicine · 2022Article
- Potential Drug-Drug Interactions in Hospitalized Medical Patients: Data From Low Resource Settings.Cureus · 2021Article
- Novel deep learning-based transcriptome data analysis for drug-drug interaction prediction with an application in diabetes.BMC bioinformatics · 2021Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug-drug interactions (DDIs) may often lead to preventable adverse drug events and health damage. Particularly in hospitals, this might be an important factor as multiple drug therapies are common. The objective of this study was to identify the frequency and levels of potential DDIs in internal medicine wards in an Iranian university hospital.
methodsA cross-sectional study was conducted by reviewing charts of 448 hospitalized patients in internal medicine wards of a teaching hospital, from November 2014 to May 2015. "Lexicomp drug interaction software" and Micromedex Drug-Reax system were used for screening the potential DDIs. The identified DDIs were categorized by level of severity. Logistic regression was applied to determine the odds ratio for specific risk factors of potential DDIs e.g., age, gender, hospital stay and number of medications.
resultsThe mean age of patients was 61 years, the length of hospital stay for patients was 9 days and the number of drugs per patient was 9. Potential interactions were detected in 386 patients. The most common types of interactions were type C (78.6%), moderate (60.9%) and delayed onset (56.5%). There was a significant association of the occurrence of potential DDIs with seven or more numbers of prescribed medications (OR: 0.048, 95% CI:0.02-0.12, p<0.0001).
conclusionThe present study has recorded a high prevalence of potential DDIs in internal medicine wards. Patients with polypharmacy were at high risk for DDIs. Education, computerized prescribing systems, drug information, and pharmaceutical care are important measures that were recommended to minimize harm associated with DDIs.
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