Evidence map›Paper›PMID 29201276›Full record

ArticleOxidative medicine and cellular longevity2017

Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats.

Rehab F Abdel-Rahman, Alyaa F Hessin, Marwan Abdelbaset, Hanan A Ogaly, Reham M Abd-Elsalam, Salah M Hassan

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06141200 (Efficacy and Safety of Roselle in Patients With Grade 1 Essential Hypertension), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06141200 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Roselle in Patients With Grade 1 Essential Hypertension: A Phase III, Randomized, Double-Blind, Double-Dummy, Active-Controlled Clinical Trial

TypeinterventionalSponsorNatural Wellness EgyptRan2024 to 2025Enrolled286ConditionsEssential HypertensionArmsNW Roselle, Captopril 25Mg Tab
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2023
    Review
  8. Article
  9. ACS omega · 2022
    Article
  10. ACS omega · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Antihypertensive Effects of theEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
  16. Article
  17. Journal of nutritional science · 2020
    Article
  18. Protective potential of curcumin in L-NAME-induced hypertensive rat model: AT1R, mitochondrial DNA synergy.International journal of physiology, pathophysiology and pharmacology · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rehab F Abdel-RahmanPharmacology Department, National Research Centre, Giza, Egypt.ORCID 0000-0002-4341-4954
Alyaa F HessinPharmacology Department, National Research Centre, Giza, Egypt.
Marwan AbdelbasetPharmacology Department, National Research Centre, Giza, Egypt.
Hanan A OgalyChemistry Department, College of Science, King Khalid University, Abha, Saudi Arabia.
Reham M Abd-ElsalamPathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Salah M HassanDepartment of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
National Research Centre · EGCairo University · EGAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the antihypertensive efficacy of a new combination therapy of

Indexed as

AnimalsAntihypertensive AgentsBlood PressureDNA DamageElectrocardiographyHeartHibiscusHypertensionKidneyLipid MetabolismMaleMalondialdehydeNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIIOleaAntihypertensive AgentsMalondialdehydeNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIIPeptidyl-Dipeptidase APlant ExtractsReactive Oxygen Species

Identifiers

PMID29201276
PMCPMC5671754
OpenAlexW2766819284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.