ArticleExperimental and therapeutic medicine2017
Bone engineering by cell sheet technology to repair mandibular defects.
Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Mesenchymal Stem Cell Sheet Engineering: Refining Cell Delivery Strategies in Regenerative Medicine.Bioengineering (Basel, Switzerland) · 2026Review
- Application of mesenchymal stem cell sheet for regeneration of craniomaxillofacial bone defects.Stem cell research & therapy · 2023Review
- Cell Sheet Technology as an Engineering-Based Approach to Bone Regeneration.International journal of nanomedicine · 2022Review
- [Advances in biomimetic modification of materials for oromaxillofacial bone regeneration and dental implant].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Review
- Tissue engineering applications in otolaryngology-The state of translation.Laryngoscope investigative otolaryngology · 2020Review
- Induced Periosteum-Mimicking Membrane with Cell Barrier and Multipotential Stromal Cell (MSC) Homing Functionalities.International journal of molecular sciences · 2020Article
- Recent advances in cell sheet technology for bone and cartilage regeneration: from preparation to application.International journal of oral science · 2019Review
- Modification of 3D printed PCL scaffolds by PVAc and HA to enhance cytocompatibility and osteogenesis.RSC advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effectiveness of bone engineering by cell sheet technology to repair canine mandibular injuries was investigated. Cell sheets were produced from canine stem cells cultured by density gradient centrifugation and osteoblast induction. A scaffold surface of polylactic-co-glycolic acid (PLGA) copolymer was wrapped with cell sheets. Mandibular injuries were created in 12 healthy dogs followed by implantation of PLGA with (experimental group; n, 6) and without (control group; n, 6) cell sheets. The progression of the implants was examined at 3, 9, and 12 weeks postoperative. At postoperative 12 weeks, the graft mostly replaced the new bone in the experimental group, compact similar to normal bone was formed at lingual position and the broken end of the bone was normally healed. The bone mass in the control group was 2.5, which was significantly lower than the 4.5 in the experimental group. The optical density of the new bone in the experimental group was significantly higher than that in the control group. The experimental group had more haversian canal and red bone marrow and contained a larger number of lamellar bone than the control group. Overall, satisfactory bone engineering containing lamellar bone can be established by cell sheet technology, which is an ideal method to repair mandibular injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.