ReviewTherapeutic advances in musculoskeletal disease2017
Evidence-based management of Raynaud's phenomenon.
Review in Therapeutic advances in musculoskeletal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- An exploratory trial of a single dose of CAM2043 (treprostinil subcutaneous depot) in SSc-related RP.Rheumatology (Oxford, England) · 2025Trial
- The effect of silver fibre gloves on Raynaud's phenomenon in patients with systemic sclerosis: a double-blind randomized crossover trial.Rheumatology (Oxford, England) · 2023Trial
- Article
- Cold responses and hormonal echoes: a comprehensive view of Raynaud's vascular dysfunction.Inflammopharmacology · 2025Review
- Raynaud's Phenomenon: A Current Update on Pathogenesis, Diagnostic Workup, and Treatment.Vascular specialist international · 2024Review
- Article
- Dynamic blood flow imaging withScientific reports · 2023Article
- Animal Models of Systemic Sclerosis: Using Nailfold Capillaroscopy as a Potential Tool to Evaluate Microcirculation and Microangiopathy: A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Raynaud's Phenomenon with Focus on Systemic Sclerosis.Journal of clinical medicine · 2022Review
- Review
- Article
- Design of Electro-Thermal Glove with Sensor Function for Raynaud's Phenomenon Patients.Materials (Basel, Switzerland) · 2021Article
- COVID-19-Induced Vestibular Neuritis, Hemi-Facial Spasms and Raynaud's Phenomenon: A Case Report.Cureus · 2020Article
- A Real-World Experience of Mycophenolate Mofetil for Systemic Sclerosis: A Retrospective Multicenter Observational Study.Archives of rheumatology · 2020Article
- Paraneoplastic Raynaud phenomenon associated with metastatic ovarian cancer: A case report and review of the literature.Gynecologic oncology reports · 2020Article
- Digit Ulcerations in a Young Woman.JAMA · 2020Article
- Management of Raynaud's phenomenon in systemic sclerosis-a practical approach.Journal of scleroderma and related disorders · 2019Review
- Raynaud's phenomenon.Journal of scleroderma and related disorders · 2019Review
- Illness perceptions in Raynaud's phenomenon: A qualitative study.Health psychology openArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Raynaud's phenomenon (RP) is relevant to the rheumatologist because it may signify an underlying connective tissue disease and also because it can be very challenging to treat, especially when it has progressed to digital ulceration or critical ischaemia. This review article discusses diagnosis (does this patient have an underlying connective tissue disease?), including the role for nailfold capillaroscopy, and treatment. Management of 'uncomplicated' RP is first described and then treatment of RP complicated by progression to digital ulceration or critical ischaemia, highlighting recent advances (including phosphodiesterase type 5 inhibition, and endothelin 1 receptor antagonism) and the evidence base underpinning these. Possible future therapies are briefly discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.