Evidence map›Paper›PMID 29201136›Full record

ArticleNature photonics2017

Depolarization signatures map gold nanorods within biological tissue.

Norman Lippok, Martin Villiger, Alexandre Albanese, Eelco F J Meijer, Kwanghun Chung, Timothy P Padera, Sangeeta N Bhatia, Brett E Bouma

Abstract read
In one paragraph

Article in Nature photonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Optical coherence tomography.Nature reviews. Methods primers · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Dual-Color Plasmonic Nanosensor for Radiation Dosimetry.ACS applied materials & interfaces · 2020
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Repeatability Assessment of Intravascular Polarimetry in Patients.IEEE transactions on medical imaging · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Norman LippokHarvard Medical School, Boston, MA, USA.
Martin VilligerHarvard Medical School, Boston, MA, USA.
Alexandre AlbaneseKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Eelco F J MeijerHarvard Medical School, Boston, MA, USA.
Kwanghun ChungInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Timothy P PaderaHarvard Medical School, Boston, MA, USA.
Sangeeta N BhatiaKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Brett E BoumaHarvard Medical School, Boston, MA, USA.

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Systems biology of lymphatic transportR01HL128168 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L., PADERA, TIMOTHY P · 2015 to 2019
$2.9M
Proteome-Driven Holistic Reconstruction of Organ-Wide Multi-Scale NetworksDP2ES027992 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHUNG, KWANGHUN · 2016 to 2021
$2.8M
Targeting lymph node metastases to prevent cancer progressionR01CA214913 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2017 to 2022
$2.0M
NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA214913NHLBI NIH HHS R01 HL128168NIBIB NIH HHS P41 EB015903NIEHS NIH HHS DP2 ES027992NIEHS NIH HHS P30 ES002109
6 · The paper itself

Abstract

Owing to their electromagnetic properties, tunability and biocompatibility, gold nanorods (GNRs) are being investigated as multifunctional probes for a range of biomedical applications. However, detection beyond the reach of traditional fluorescence and two-photon approaches and quantitation of their concentration in biological tissue remain challenging tasks in microscopy. Here we show how the size and aspect ratio that impart GNRs with their plasmonic properties also make them a source of entropy. We report on how depolarization can be exploited as a strategy to visualize GNR diffusion and distribution in biologically relevant scenarios

Identifiers

PMID29201136
PMCPMC5703429

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.