Evidence map›Paper›PMID 29201099›Full record

ArticleIranian journal of pharmaceutical research : IJPR2017

Synthesis and Biological Evaluation of Thiosemicarbazide Derivatives Endowed with High Activity toward

Soroush Sardari, Samaneh Feizi, Ali Hossein Rezayan, Parisa Azerang, Seyyed Mohammad Shahcheragh, Ghazaleh Ghavami, Azizollah Habibi

Abstract read
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soroush SardariDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnoloogy Research Center, Pasteur Institute of Iran, Tehran, Iran.
Samaneh FeiziDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnoloogy Research Center, Pasteur Institute of Iran, Tehran, Iran.
Ali Hossein RezayanDepartment of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran.
Parisa AzerangDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnoloogy Research Center, Pasteur Institute of Iran, Tehran, Iran.
Seyyed Mohammad ShahcheraghDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnoloogy Research Center, Pasteur Institute of Iran, Tehran, Iran.
Ghazaleh GhavamiDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnoloogy Research Center, Pasteur Institute of Iran, Tehran, Iran.
Azizollah HabibiFaculty of Chemistry, Kharazmi University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiosemicarbazides are potent intermediates for the synthesis of pharmaceutical and bioactive materials and thus, they are used extensively in the field of medicinal chemistry. The imine bond (-N=CH-) in this compounds are useful in organic synthesis, in particular for the preparation of heterocycles and non-natural β-aminoacids. In this paper the synthesis of some new thiosemicarbazide derivatives by condensation reaction of various aldehydes or ketones with 4-phenylthiosemicarbazide or thiosemicarbazide is reported. This synthesis method has the advantages of high yields and good bioactivity. The structures of these compounds were confirmed by IR, mass,

Indexed as

Anti-tubercular activityBiological evaluationMedicinal chemistryMycobacterium bovisThiosemicarbazide derivatives

Identifiers

PMID29201099
PMCPMC5610766

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.