ReviewInternational journal of endocrinology and metabolism2017
Hemostasis in Overt and Subclinical Hyperthyroidism.
Review in International journal of endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- The Differential Effects of Propylthiouracil and Methimazole as Graves' Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial.Frontiers in endocrinology · 2021Trial
- Thyroid storm-induced cardiovascular complications and modalities of therapy: Up-to-date review.World journal of critical care medicine · 2025Review
- Endothelial dysfunction in children with newly diagnosed Graves' disease.European journal of pediatrics · 2023Article
- Unprovoked Isolated Pulmonary Embolism and Graves' Disease in a Patient With Dyspnea: A Case Report.Cureus · 2022Article
- Venous Thromboembolism and Thymic Hyperplasia in the Setting of Silent Graves' Disease.Cureus · 2022Article
- Cardiac manifestations in hyperthyroidism.Reviews in cardiovascular medicine · 2022Review
- Potential relationships between COVID-19 and the thyroid gland: an update.The Journal of international medical research · 2022Review
- COVID-19 as a trigger of cerebral venous sinus thrombosis in a patient with autoimmune hyperthyroidism: a case report.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022Article
- The Effects of Previous Thyroid Disease on the Susceptibility to, Morbidity of, and Mortality Due to COVID-19: A Nationwide Cohort Study in South Korea.Journal of clinical medicine · 2021Article
- COVID-19 and Thyroid Diseases: A Bidirectional Impact.Journal of the Endocrine Society · 2021Review
- Portal and Mesenteric Vein Thrombosis Associated with Hyperthyroidism.The American journal of case reports · 2021Article
- Challenges in the Management of Atrial Fibrillation With Subclinical Hyperthyroidism.Frontiers in endocrinology · 2021Review
- Platelet function in cats with hyperthyroidism.Journal of feline medicine and surgery · 2020Article
- Thyroid Storm, Rhabdomyolysis, and Pulmonary Embolism: An Unusual Triad Case Report.Clinical practice and cases in emergency medicine · 2020Article
- Subclinical Hyperthyroidism Could Predict Poor Outcomes in Patients With Acute Ischemic Stroke Treated With Reperfusion Therapy.Frontiers in neurology · 2019Article
- Hyperthyroidism as a Precipitant Factor for Cerebral Venous Thrombosis: A Case Report.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThere are contradictory results on the effect of hyperthyroidism on hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). The present review focuses on hemostatic changes in overt and subclinical hyperthyroidism.
methodsA systematic literature search was conducted employing MEDLINE database. The following words were used for the search: Hyperthyroidism; thyrotoxicosis; Graves disease; goiter, nodular; hemostasis; blood coagulation factors; blood coagulation disorders; venous thromboembolism; bleeding; fibrinolysis. The articles that were related to hyperthyroidism and hemostasis are used in this manuscript.
resultsHyperthyroidism, either overt or subclinical, renders a hypercoagulable state, although there are several studies with contradictory findings in the literature. Hypercoagulability may be caused by an increase in the level of various coagulation factors such as factor (F) VIII, FX, FIX, von Willebrand F (vWF), and fibrinogen, while hypofibrinolysis by changes in coagulation parameters such as a decrease in plasmin and plasmin activator or an increase in α2-antiplasmin, plasminogen activator inhibitor-1 and thrombin activatable fibrinolysis inhibitor.
conclusionsAlthough many reports are in favor of a hypercoagulable state in overt hyperthyroidism but this finding at the biochemical level and its clinical implication, on the occurrence of VTE, has yet to be confirmed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.