Evidence map›Paper›PMID 29201016›Full record

ReviewFrontiers in microbiology2017

The Promise of Systems Biology Approaches for Revealing Host Pathogen Interactions in Malaria.

Meghan Zuck, Laura S Austin, Samuel A Danziger, John D Aitchison, Alexis Kaushansky

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. A globalBMC bioinformatics · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meghan ZuckCenter for Infectious Disease Research, formerly Seattle Biomedical Research Institute, Seattle, WA, United States.
Laura S AustinCenter for Infectious Disease Research, formerly Seattle Biomedical Research Institute, Seattle, WA, United States.
Samuel A DanzigerCenter for Infectious Disease Research, formerly Seattle Biomedical Research Institute, Seattle, WA, United States.
John D AitchisonCenter for Infectious Disease Research, formerly Seattle Biomedical Research Institute, Seattle, WA, United States.
Alexis KaushanskyCenter for Infectious Disease Research, formerly Seattle Biomedical Research Institute, Seattle, WA, United States.

Funding

Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DUDLEY, AIMEE M · 2006 to 2016
$30.6M
TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
Structure-Function Mapping of the Nuclear Pore Complex-RenewalR01GM112108 · NIGMS · ROCKEFELLER UNIVERSITY · PI JOHN D. AITCHISON, MICHAEL P ROUT · 2015 to 2026
$9.1M
Perturbations of host cell signaling by a complex hepatotropic pathogenR01GM101183 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI KAUSHANSKY, ALEXIS · 2013 to 2021
$3.6M
Applying the principle of synthetic lethality to virus-host protein-protein interactions as a novel approach for antiviral developmentR21AI124266 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI AITCHISON, JOHN D. · 2016 to 2017
$520k
Investigating hepatocyte signaling driven by host-pathogen interactionsR00AI111785 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI KAUSHANSKY, ALEXIS · 2016 to 2017
$498k
NIAID NIH HHS R00 AI111785NIAID NIH HHS R21 AI124266NIGMS NIH HHS P41 GM109824NIGMS NIH HHS P50 GM076547NIGMS NIH HHS R01 GM101183NIGMS NIH HHS R01 GM112108
6 · The paper itself

Abstract

Despite global eradication efforts over the past century, malaria remains a devastating public health burden, causing almost half a million deaths annually (WHO, 2016). A detailed understanding of the mechanisms that control malaria infection has been hindered by technical challenges of studying a complex parasite life cycle in multiple hosts. While many interventions targeting the parasite have been implemented, the complex biology of

Indexed as

computational modelinglivermalariaomics-technologiesplasmodiumsystems biology

Identifiers

PMID29201016
PMCPMC5696578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.