Evidence map›Paper›PMID 29200982›Full record

Trial reportJournal of the International Society of Sports Nutrition2017

Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial.

Håvard Hamarsland, Anne Lene Nordengen, Sigve Nyvik Aas, Kristin Holte, Ina Garthe, Gøran Paulsen, Matthew Cotter, Elisabet Børsheim, Haakon B Benestad, Truls Raastad

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02968888 (Effects of Whey and Casein Supplementation on Acute Anabolic Responses in Muscle After Strength Training in Young and Elderly), which is not on this map. Cited by 28 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 6 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02968888 nacompletednot on this map

Effects of Whey and Casein Supplementation on Acute Anabolic Responses in Muscle After Strength Training in Young and Elderly

TypeinterventionalSponsorNorwegian School of Sport SciencesRan2014 to 2017Enrolled43ConditionsHealthy, Young, ElderlyArmsStrength training, Milk 1%, Whey protein concentrate 80, Native whey
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 6 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  19. The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Håvard HamarslandDepartment of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014 Ullevål Stadion, 0806 Oslo, Norway.
Anne Lene NordengenDepartment of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014 Ullevål Stadion, 0806 Oslo, Norway.
Sigve Nyvik AasDepartment of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014 Ullevål Stadion, 0806 Oslo, Norway.
Kristin HolteDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
Ina GartheNorwegian Olympic Federation, Oslo, Norway.
Gøran PaulsenDepartment of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014 Ullevål Stadion, 0806 Oslo, Norway.
Matthew CotterArkansas Children's Nutrition Center, Little Rock, AR USA.
Elisabet BørsheimArkansas Children's Nutrition Center, Little Rock, AR USA.
Haakon B BenestadSection of Anatomy, Institute of Basis Medical Sciences, University of Oslo, Oslo, Norway.
Truls RaastadDepartment of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014 Ullevål Stadion, 0806 Oslo, Norway.
Norwegian School of Sport Sciences · NOUniversity of Oslo · NOArkansas Children's Hospital · USUniversity of Arkansas for Medical Sciences · US

Funding

RESOURCE CORE 3: ANALYTICAL COREP30AG028718 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI WEI, JEANNE Y · 2011 to 2015
$5.1M
Effects of amino acids on regional lipid metabolismR01AG033761 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BORSHEIM, ELISABET · 2009 to 2013
$1.6M
NIA NIH HHS P30 AG028718NIA NIH HHS R01 AG033761
6 · The paper itself

Abstract

backgroundProtein intake is essential to maximally stimulate muscle protein synthesis, and the amino acid leucine seems to possess a superior effect on muscle protein synthesis compared to other amino acids. Native whey has higher leucine content and thus a potentially greater anabolic effect on muscle than regular whey (WPC-80). This study compared the acute anabolic effects of ingesting 2 × 20 g of native whey protein, WPC-80 or milk protein after a resistance exercise session.

methods

resultsNative whey increased blood leucine concentrations more than WPC-80 and milk (

conclusionsDespite higher-magnitude increases in blood leucine concentrations with native whey, it was not superior to WPC-80 concerning effect on muscle protein synthesis and phosphorylation of p70S6K during a 5-h post-exercise period. Native whey increased phosphorylation of p70S6K and muscle protein synthesis rates to a greater extent than milk during the 5-h post exercise period.

trial registrationThis study was retrospectively registered at clinicaltrials.gov as NCT02968888.

Indexed as

Dietary SupplementsResistance TrainingSports Nutritional Physiological PhenomenaCross-Over StudiesDouble-Blind MethodFemaleHealthy VolunteersHumansLeucineMaleMuscle ProteinsMuscle, SkeletalProtein BiosynthesisWhey ProteinsYoung AdultLeucineMuscle ProteinsWhey ProteinsAmino acidsNutritionProtein qualityResistance trainingSkeletal muscleStable isotopesSupplementation

Identifiers

PMID29200982
PMCPMC5697397
OpenAlexW2769109349

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.