ArticleThrombosis journal2017
vWF/ADAMTS13 is associated with on-aspirin residual platelet reactivity and clinical outcome in patients with stable coronary artery disease.
Article in Thrombosis journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00222261 (Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- von Willebrand factor, ADAMTS-13, and thrombospondin 1 in relation to clinical outcomes in elderly patients with a recent myocardial infarction.Research and practice in thrombosis and haemostasis · 2023Article
- Von Willebrand factor in diagnostics and treatment of cardiovascular disease: Recent advances and prospects.Frontiers in cardiovascular medicine · 2022Review
- Von Willebrand factor collagen-binding capacity predicts in-hospital mortality in COVID-19 patients: insight from VWF/ADAMTS13 ratio imbalance.Angiogenesis · 2021Article
- Shear Stress-Induced Activation of von Willebrand Factor and Cardiovascular Pathology.International journal of molecular sciences · 2020Review
- Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury.Acta pharmaceutica Sinica. B · 2019Article
- AFM Imaging Reveals Multiple Conformational States of ADAMTS13.Journal of biological engineering · 2019Article
- Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation.Frontiers in pharmacology · 2019Article
- ADAMTS13: An Emerging Target in Stroke Therapy.Frontiers in neurology · 2019Review
- Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF). ADAMTS13 is a metalloprotease cleaving ultra large vWF multimers into less active fragments.Our aim was to investigate whether ADAMTS13 and vWF/ADAMTS13 ratio were associated with high RPR, and further with clinical endpoints after 2 years.
methodsStable aspirin-treated CAD patients (
resultsThe number of patients with high RPR was 258 (25.8%). Their serum thromboxane B
conclusionThese results indicate that ADAMTS13 is of importance for RPR, and that it in combination with vWF also is associated with clinical endpoints in stable CAD patients on aspirin.
trial registrationClinicaltrials.gov NCT00222261. Registered 13.09.2005. Retrospectively registered.
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