Evidence map›Paper›PMID 29200908›Full record

ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2017

Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study.

Hyun Seok Bang, Dae Yun Seo, Young Min Chung, Do Hyung Kim, Sam-Jun Lee, Sung Ryul Lee, Hyo-Bum Kwak, Tae Nyun Kim, Min Kim, Kyoung-Mo Oh and 3 more

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In one paragraph

Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Article
  8. Ursolic acid in health and disease.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hyun Seok BangDepartment of Physical Education, College of Health, Social Welfare and Education, Tong Myong University, Busan 48520, Korea.
Dae Yun SeoNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK 21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea.
Young Min ChungSchool of Free Major, Tong Myong University, Busan 48520, Korea.
Do Hyung KimDepartment of Physical Education, Changwon National University, Changwon 51140, Korea.
Sam-Jun LeeDepartment of Physical Education, College of Health, Social Welfare and Education, Tong Myong University, Busan 48520, Korea.
Sung Ryul LeeNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK 21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea.
Hyo-Bum KwakDepartment of Kinesiology, Inha University, Incheon 22212, Korea.
Tae Nyun KimNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK 21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea.
Min KimNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK 21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea.
Kyoung-Mo OhDepartment of Sports Leisure, College of Kyungsang, Busan 47583, Korea.
Young Jin SonDepartment of Sports Industry, Busan University of Foreign Studies, Busan 46234, Korea.
Sanghyun KimDepartment of Sports Science, College of Natural Science, Chonbuk National University, Jeonju 54896, Korea.
Jin HanNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK 21 Plus Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea.
Tongmyong University · KRChangwon National University · KRInha University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group). Participants were trained according to the RT program (60~80% of 1 repetition, 6 times/week), and the UA group was additionally given UA supplementation (450 mg/day) for 8 weeks. Blood samples were obtained before and after intervention, and cortisol, BNP, myoglobin, CK, CK-MB, and LDH levels were analyzed. Subjects who underwent RT alone showed no significant change in body composition and markers of skeletal muscle damage, whereas RT+UA group showed slightly decreased body weight and body fat percentage and slightly increased lean body mass, but without statistical significance. In addition, UA supplementation significantly decreased the BNP, CK, CK-MB, and LDH levels (p<0.05). In conclusion, UA supplementation alleviates increased skeletal muscle damage markers after RT. This finding provides evidence for a potential new therapy for resistance-trained men.

Indexed as

Resistance-trained menResistance trainingSkeletal muscle damage markersUrsolic acid

Identifiers

PMID29200908
PMCPMC5709482
OpenAlexW2770103383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.