ArticleAnnals of dermatology2017
Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways.
Article in Annals of dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial.Lasers in medical science · 2019Trial
- [Clinical application of photobiomodulation in trauma repair and medical aesthetics].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024Article
- Article
- Extremely Low-Frequency Electromagnetic Fields Increase Cytokines in Human Hair Follicles through Wnt/β-Catenin Signaling.Biomedicines · 2022Article
- Comparison of low-level light therapy and combination therapy of 5% minoxidil in the treatment of female pattern hair loss.Lasers in medical science · 2021Article
- Proposed mechanisms of low-level light therapy in the treatment of androgenetic alopecia.Lasers in medical science · 2021Review
- Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway.International journal of molecular sciences · 2020Article
- The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth.Annals of dermatology · 2019Article
- Photobiomodulation for the management of alopecia: mechanisms of action, patient selection and perspectives.Clinical, cosmetic and investigational dermatology · 2019Article
- 5-Hydroxy-4'-Nitro-7-Propionyloxy-Genistein Inhibited Invasion and Metastasis via Inactivating Wnt/b-Catenin Signal Pathway in Human Endometrial Carcinoma Ji Endometrial Cells.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Role of Low-Level Light Therapy (LLLT) in Androgenetic Alopecia.Journal of cutaneous and aesthetic surgeryReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth.
objectiveThe aim of this study was to investigate the effect of different wavelengths of light-emitting diode (LED) irradiation on the proliferation of cultured hDPCs and on the growth of human hair follicles (HFs)
methodsWe examined the effect of LED irradiation on Wnt/β-catenin signaling and mitogen-activated protein kinase (MAPK) pathways in hDPCs. Anagen HFs were cultured with LED irradiation and elongation of each hair shaft was measured.
resultsThe most potent wavelength in promoting the hDPC proliferation is 660 nm and 830 nm promoted hDPC proliferation to a lesser extent than 660 nm. Various wavelengths significantly increased β-catenin, Axin2, Wnt3a, Wnt5a and Wnt10b mRNA expression. LED irradiation significantly increased β-catenin and cyclin D expression, and the phosphorylation of MAPK and extracellular signal-regulated kinase (ERK). HFs irradiated with 415 nm and 660 nm grew longer than control.
conclusionOur result suggests that LED has a potential to stimulate hDPC proliferation via the activation of Wnt/β-catenin signaling and ERK pathway. To our best knowledge, this is the first report which investigated that the effect of various wavelengths of LED on hDPC proliferation and the underlying mechanisms.
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