ArticlePharmacognosy magazine
A Study of the Anti-Cancer Effects of the Hexane Fraction of the Methanol Extract of Forsythiae Fructus.
Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity.Frontiers in pharmacology · 2021Review
- UPLC/Q-TOF MS Screening and Identification of Antibacterial Compounds inFrontiers in pharmacology · 2021Review
- Neuroprotective Effects of an Aqueous Extract ofMolecules (Basel, Switzerland) · 2019Article
- Determination of progesterone compounds in the crude methanol extract of benalu duku leaves.Veterinary world · 2019Article
- Anti-Cancer Effects ofCurrent urology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundForsythiae Fructus (FF) is a well-known medicinal herb derived from the dried fruits of
objectiveAlmost all herbal medicines are derived from water extracts, which suggests different extraction methods might enhance the practical efficacies of herbal medicines. In this study, the authors further investigated the most potential anti-cancer fraction, that is, the hexane fraction (FFH) of the methanol extract (FFM) of the dried fruits of MATERIALS AND
methodsFFH was investigated by measuring its effects on the viability and apoptotic death of PC-3 cells (a prostate cancer cell line), on the expression levels of Bcl-2, Bax, cytochrome c, procaspase-9, procaspase-3 and PARP, and caspase-3 activity.
resultsFFH significantly accelerated apoptotic cell death and decreased the protein levels of Bcl-2, procaspase-9, and procaspase-3.
conclusionFFH can act as a pro-oxidative agent and induce the apoptosis of prostate cancer cells. SUMMARY: Hexane fraction of the methanol extract of Forsythiae Fructus (FFH) at a concentration more than 50 µg/mL significantly reduced PC-3 cell viabilityFFH time and dose dependently elevated intracellular ROS levels and increased the proportion of cells arrested in the G
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