Evidence map›Paper›PMID 29200735›Full record

ArticlePharmacognosy magazine

Therapeutic Effects of

Yanmei Cao, Cuicui Gu, Fangli Zhao, Yuanlin Tang, Xiaobing Cui, Le Shi, Li Xu, Lian Yin

Open access · greenAbstract read
In one paragraph

Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Effects and molecular mechanisms ofFrontiers in pharmacology · 2025
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  8. Chinese herbal medicines · 2021
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  9. Integrated Strategy FromFrontiers in pharmacology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yanmei CaoDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Cuicui GuDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Fangli ZhaoDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Yuanlin TangDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Xiaobing CuiDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Le ShiDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Li XuDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Lian YinDepartment of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, 210023 Nanjing, China.
Nanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectiveTo evaluate the improving blood rheology and anti-inflammatory properties of MATERIALS AND

methodsCO at 0.26, 0.53, and 1.04 g/kg and ACO at 0.38, 0.75, and 1.5 g/kg were administered to acute blood stasis model Wistar rats for 3 days. Whole blood viscosity, plasma viscosity, and the levels of interleukin-6 (IL-6), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), and cyclooxygenase-2 (COX-2) in the plasma were measured. HPLC-QTOF/MS/MS method was used to identify the major constituents of ACO; the properties of two representative components (cyasterone and chikusetsusaponin IV) from ACO on thrombin-induced human umbilical vein endothelial cells damage model were also assessed by the levels of thromboxane A2 (TXA2), endothelin (ET), malondialdehyde (MDA), COX-2, endothelial nitric oxide synthase (eNOS), and superoxide dismutase (SOD).

resultsCO and ACO significantly reduced whole blood viscosity, plasma viscosity, and levels of IL-6, NO, TNF-α, and COX-2

conclusionCO and ACO possessed significant improving blood rheology and anti-inflammatory effects on acute blood stasis model rats and the representative components Cyasterone and chikusetsusaponin IV showed significant anti-inflammatory, antioxidant, and anticoagulant effects SUMMARY:

Indexed as

Acute blood stasis model ratsanti-inflammatoryCyathula officinalis KuanHPLC-QTOF/MS/MSimproving blood rheology

Identifiers

PMID29200735
PMCPMC5701413
OpenAlexW2768343935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.